Vitamin D effects on mother, placenta and fetus
S.V. MALTSEV¹, G.Sh. MANSUROVA², A.M. ZAKIROVA¹, L.I. MALTSEVA3, E.N. VASILEVA3
¹Kazan State Medical University, 39 Butlerov St., Kazan, Russian Federation, 420012
²Kazan (Volga) Federal University, 18 Kremlevskaya St., Kazan, Russian Federation, 420008
3Kazan State Medical Academy, 36 Butlerov St., Kazan, Russian Federation, 420012
Maltsev S.V. ― D. Med. Sc., Professor of the Department of propaedeutics of children’s diseases, Faculty pediatrics with the course of childhood diseases of the Medical Faculty, tel. (843) 221-94-34, e-mail: maltc@mail.ru
Mansurova G.Sh. ― Assistant Professor of the Department of emergency medicine and simulation medicine of the Institute of Fundamental Medicine and Biology, tel. +7-917-390-79-20, e-mail: gsm98@mail.ru
Zakirova A.M. ― Cand. Med. Sc., Associate Professor of the Department of propaedeutics of children’s diseases, Faculty pediatrics with the course of childhood diseases of the Medical Faculty, tel. +7-927-033-93-41, e-mail: azakirova@gmail.com
Maltseva L.I. ― D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology №1, tel. +7-905-314-40-51, e-mail: laramalc@mail.ru
Vasileva E.N. ― Competitor of the Department of Obstetrics and Gynecology №1, tel. +7-903-345-86-65, e-mail: elnikvas@mail.ru
The article presents the literature on vitamin D metabolism in the body, the «classical» and «nonclassical» metabolites functions ― 25(ОН) D3 и 1,25(ОН)2D3. The characteristics of synthesis, metabolism and physiological effects of vitamin D in mother, placenta and fetus, nature of transplacental transfer of metabolites during pregnancy, the role of Vitamin D ― receptors and placental hormones in providing placenta functions during pregnancy. The results of in-house studies of authors about an estimated level of 25(ОН) D3 in pregnant women and their newborns, peculiarities of pregnancy and the health of infants, and children during the first months of life, with the pregnant pathology and varying degree of Vitamin D are studied.
Key words: vitamin D, women, metabolism during pregnancy, provision in the pathology of pregnant women, newborns and children during the first 3 months of life.
REFERENCES
1. Gupta V. Vitamin D: Extra-skeletal effects. J. Med. Nutr. Nutraceut, 2012, 1, pp. 17-26.
2. Kebashni Thandrayen, John M. Pettifor. Endocrinology and Metabolism. Clinics of North America, 2010, vol. 39, issue 2, pp. 303-320.
3. Gromova O.A., Torshin I.Yu. Vitamin D – smena paradigmy []. Moscow: TORUS PRESS, 2015. 464 p.
4. Baeke F., Takiishi T., Korf H., Gysemans C., Mathieu C. Vitamin D: modulator of the immune system. Curr. Opin. Pharmacol, 2010, 10, issue 4, pp. 482-496.
5. Mal’tsev S.V., Arkhipova N.N., Shakirova E.M., Kolesnichenko T.V. Features of phosphate-calcium metabolism in neonates and premature infants. Prakticheskaya meditsina, 2009, no. 7 (39), pp. 9-13 (in Russ.).
6. Shin J.S., Choi M.Y., Longtine M.S., Nelson D.M. Vitamin D effects on pregnancy and the placenta. Placenta, 2010, vol. 31, issue 12, pp. 1027-1034.
7. Holick M.F. High prevalence of vitamin D inadecuacy fnd implications for health. Mayo Clin. Proc, 2006, 81, pp. 353-373.
8. Zakharova I.N., Vasil’eva S.V., Dmitrieva Yu.A., Mozzhukhina M.V. Vitamin D in pediatric practice. Farmateka, 2014, no. 1, pp. 6-17 (in Russ.).
9. Spirichev V.B. On the biological effects of vitamin D. Pediatriya, 2011, 90 (6), pp. 113-119 (in Russ.).
10. Wacker M., Holick M.F. Vitamin D-effects on skeletal and extra skeletal health and the need for supplementation. Nutrients, 2013, 5 (1), pp. 111-148.
11. Reusheva S.V., Panicheva E.A., Pastukhova S.Yu., Reushev M.Yu. The value of vitamin D deficiency in the development of human diseases. Uspekhi sovremennogo estestvoznaniya, 2013, 11, pp. 27-31 (in Russ.).
12. Natsional’naya programma “Nedostatochnost’ vitamina D u detey i podrostkov v Rossiyskoy Federatsii: sovremennye podkhody k korrektsii” [The national program “Vitamin D deficiency in children and adolescents in the Russian Federation: modern approaches to correction”]. Moscow, 2015. 112 p.
13. Novakovic B., Sibson M., Ng H.K., Manuelpillai U., Rakyan V., Down T. et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J. Biol. Chem, 2009, 28, pp. 14838-14848.
14. Kovacs C.S., Kronenberg H.M. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr. Rev, 1997, vol. 18 (6), pp. 832-872.
15. Ivanov D.O., Petrenko Yu.V., Shemyakina O.O. Vitamin D in the mother-placenta-fetus. Detskaya meditsina Severo-Zapada, 2012, vol. 3, no. 4, pp. 43-48 (in Russ.).
16. Surkov D.N., Ivanov D.O., Obolonskiy A.I. et al. Current strategies of nursing preterm infants. Detskaya meditsina Severo-Zapada, 2012, vol. 3, no. 1, pp. 4-9 (in Russ.).
17. Simmonds C.S. et al. Role of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in regulating mineral homeostasis during fetal development. Crit. Rev. Eukaryot Gene Expr, 2010, vol. 20 (3), pp. 235-273.
18. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol. Metab. Clin. North. Am, 2010, 39, 2, pp. 365-379.
19. Díaz L., Noyolaartínez N., Barrera D., Hernández G., Avila E., Halhali A., Larrea F. Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts. J. Reprod. Immunol, 2009, 81, pp. 17-24.
20. Barrera D., Avila E., Hernández G., Méndez I., González L., Halhali A., Larrea F., Morales A., Díaz L. Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts. Reproductive Biology and Endocrinology, 2008, 6, 3.
21. Evans K.N., Bulmer J.N., Kilby M.D., and Hewison M. Vitamin D and placental-decidual function. J. Soc. Gynecol. Investig, 2004, 11, pp. 263-271.
22. Barrera D., Avila E., Hernández G., Halhali A., Biruete B., Larrea F., Díaz L. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. Journal of Steroid Biochemistry and Molecular Biology, 2007, 103, pp. 529-532.
23. Bagot C.N., Troy P.J., Taylor H.S. Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Therapy, 2000, 7, pp. 1378-1384.
24. Tuan R.S., Moore C.J., Brittingham J.W., Kirwin J.J., Akins R.E., Wong M. In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. Journal of Cell Science, 1991, 98, pp. 333-342.
25. Stephanou A., Ross R., Handwerger S. Regulation of human placental lactogen expression by 1,25-dihydroxyvitamin D3. Endocrinology, 1994.
26. Du H., GS, Lalwani S.I., Taylor H.S. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Molecular Endocrinology, 2005, 19, pp. 2222-2233.
27. Selvaraj P. Vitamin D, vitamin D receptor, and cathelicidin in the treatment. Vitam. Horm, 2011, 86, pp. 307-325.
28. Mehta S., Giovannucci E., Mugusi F.M., Spiegelman D., Aboud S., Hertzmark E. et al. Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia, and mortality. PLoS One, 2010, 5, 8770
29. Natarajan C.R., Sankar M.J., Agarwal R., Pratar O.T., Jain V., Gupta N., Gupta A.K., Deorari A.K., Paul V.K., Sreenivas V. Trial of daily vitamin D supplemention in preterm infants. Pediatrics, 2014, 133 (3), pp. 628-634.
30. Shin J.S., Choi M.Y., Longtine M.S., Nelson D.M. Vitamin D effects on pregnancy and the placenta, 2010, vol. 31, issue 12, pp. 1027-1034.
31. Mal’tseva L.I., Polukeeva A.S., Garifullova Yu.V. The role of vitamin D in maintaining health and reproductive capacity of women. Prakticheskaya meditsina, 2015, no. 1 (86), pp. 30-36 (in Russ.).


