A.V. GANEYEVA¹, R.I. GABIDULLINA², S.D. MAYANSKAYA²

¹Kazan (Volga) Federal University, 2 Vishnevskiy Str., Kazan, Russian Federation, 420059

²Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

 Ganeeva A.V. — obstetrician-gynecologist, tel. +7-917-253-15-78, e-mail: a.v.ganeeva@gmail.com

Gabidullina R.I. — D. Med. Sc., Professor of the Department of Obstetrics and Gynecology No. 2, tel. +7-917-289-93-10, e-mail: ru.gabidullina@yandex.ru

Mayanskaya S.D. — D. Med. Sc., Professor of Hospital Therapy with a course of Endocrinology, tel. +7-987-297-06-15, e-mail: smayanskaya@mail.ru

The article presents the analysis of the course of pregnancy in 150 women with hypertensive disorders and without them. The aim of the study was to assess the potential influence of short-term and long-term variability of systolic and diastolic blood pressure (BP) in pregnant women on the preeclampsia risk. The results of study show that in the absence of hypertension disorders, short-term and long-term BP variability stayed low and stable during all pregnancy. However, in case of hypertensive disorders, whether chronic or gestational, the BP variability, both short-term and long-term, was higher. Also, the high long-term variability of systolic arterial pressure in the second trimester was characteristic of women whose pregnancy was afterwards complicated with preeclampsia in the third trimester. The obtained results allow to suggest that high long-term variability of systolic BP in the second trimester could be used as a predictor of preeclampsia in pregnant women without initial hypertensive disorders.

Key words: short-term variability of arterial blood pressure, long-term variability of arterial blood pressure, preeclampsia, chronic hypertension.

REFERENCES

1. Redman C W G. Eclampsia still kills. Br Med J (Clin Res Ed), 1988, № 296 (6631), pp. 1209–1210.
2. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia, 2014. 4
3. Amaral L.M., Wallace K., Owens M., LaMarca B. Pathophysiology and Current Clinical Management of Preeclampsia. Curr Hypertens Rep, 2017, №19 (8). 61 p.
4. Zaporozhets E.E., Shuvalova M.P., Tsyimlyakova L.M., Frolova O.G., Ogryizko E.V., Suhanova L.P. The main indicators of the activities of the mother and child health service in the Russian Federation. Statistical form number 32 for 2012, 2013, pp. 48-50.
5. Allen R., Aquilina J. Prospective observational study to determine the accuracy of first trimester serum biomarkers and uterine artery Dopplers in combination with maternal characteristics and arteriography for the prediction of women at risk of preeclampsia and other adverse pregnancy outcomes. J Matern Fetal Neonatal Med, 2017, № 16, p.1-17.
6. Sperling J.D., Gossett D.R. Screening for Preeclampsia and the USPSTF recommendations. JAMA, 2017, №317, pp.1629-1630.
7. Parikh N.I., Gonzalez J. Preeclampsia and hypertension: Courting a long while: Time to make it official. JAMA Intern Med. 2017, http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2619524
8. Adamian L.V., Artimuk N.V., Bashmakova N.V. et al. Hypertensive disoders in pregnancy, delivery and postdelivery period. Preeclampsia. Eclampsia. Clinical recommendations. 2016, pp.11-12.
9. Zilber A.P. Obstetrics as an anesthesiologist’s view, 1997. 9 p.
10. Ostroumova O.A. Value of blood pressure variability in clinical practice. Сapabilities of amlodipine in reduction of short – term blood pressure variability (by results of Russion programme «Variation». System hypertensions, 2014, №1 (11), pp. 11-16.
11. Parati G., Pomidossi G., Albini F. et al. Relationship of 24-hour blood pressure mean and variability to severity of target-organ damage in hypertension. J Hypertens, 1987, № 5, pp. 93–98.
12. Frattola A., Parati G., Cuspidi C. et al. Prognostic value of 24-hour blood pressure variability. J Hypertens, 1993, № 11, pp. 1133–1137.
13. Rothwell P.M. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet, 2010, № 375, pp. 895–905.
14. Muntner P., Shimbo D., Tonelli M. et al. The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994. Hypertension. – 2011. – №57, pp. 160–166.
15. NICE Guidelines 2011. Hypertension: management of hypertension in adults in primary care. http://www.nice.org.uk/CG127.