A.N. NURIAKHMETOV^1,2*, I.F. AKHTYAMOV^1,2, M.I. ARLEEVSKAYA³, A.I. KUDRYAVTSEV^2,3, F.M. SAID¹, T.Yu. NURIAKHMETOVA¹

¹Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

²Republican Clinical Hospital, 138 Orenburgskiy tract, Kazan, Russian Federation, 420064

³Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of the Russian Federation, 36 Butlerov Str., Kazan, Russian Federation, 420012

Nuriakhmetov A.N. — postgraduate student of the Department of Traumatology, Orthopedics and SES, tel. (843) 231-21-99, e-mail: jouric@yandex.ru

Akhtyamov I.F. — D.Sc. (medicine), Professor, Head of the Department of Traumatology, Orthopedics and SES, tel. (843) 231-21-99, e-mail: yalta60@mail.ru

Arleyevskaya M.I. — PhD (medicine), Senior Researcher of Central Scientific Research Laboratory, tel. (843) 203-60-52, e-mail: marleev@mail.ru

Kudryavtsev A.I.— PhD (medicine), Head of the Orthopedic Department No. 2, tel. (843) 231-21-99, e-mail: kdalex@bk.ru

Said M.F. — postgraduate student of the Department of Traumatology, Orthopedics and SES, tel.: (843) 231-21-99, e-mail: Firassss86@gmail.com, ORCID ID: 0000-0002-7712-3266

Nuriakhmetova T.Yu. — postgraduate student of the Department of Hospital Therapy, tel. (843) 231-21-99, e-mail: Tatiana.afanaseva.ksmu@gmail.com

 Physical injury is one of environmental factors, which can affect the onset and severity of such diseases as rheumatoid arthritis, chronic juvenile arthritis, Still’s disease, spondyloarthritis, in particular, psoriatic arthritis, gout and pseudogout. The literature review is dedicated to the role of trauma in inducing rheumatic diseases, as well as possible mechanisms of pathogenesis. Factors contributing to posttraumatic arthritis development by inflammatory pathway are discussed, including genetic predisposition, epigenetic changes, mechanobiologic and inflammatory factors. The hypotheses of trauma-induced chronic inflammatory arthritis are reviewed, in particular, interplay with microbiota, “deep Koebner phenomenon” and “synovio-enthesial complex” in psoriatic arthritis, the role of neuropeptides, local and systemic hypoxia due to tissue injury, ischemic reperfusion, exposure of mitochondrial structures and nuclear antigens from necrotized tissue, and cartilage debris adhesion on synovial membrane.

Key words: trauma, posttraumatic inflammatory arthritis, trigger.

(For citation: Nuriakhmetov A.N., Akhtyamov I.F., Arleyevskaya M.I., Kudryavtsev A.I., Said M.F., Nuriakhmetova T.Yu. Practical Medicine. 2018)

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