A.A. EVSTRATOV¹, I.A. BARKOVSKIY², D.R. SABIROVA³

¹Republican Clinical Hospital of the MH of RT, 138 Orenburskiy Trakt, Kazan, Russian Federation, 420064

²State Maternity hospital №1, 42 Varvarskaya Str., Nizhny Novgorod, Russian Federation, 603006

³Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012 

Evstratov A.A. ― Head of Intensive Care Unit №2, tel. +7-987-296-22-24, e-mail: virineia2005@mail.ru

Barkovsky I.A. ― Head of Anesthesiology and Intensive Care Unit, tel. +7-910-383-34-99, e-mail: rod_dom1@mail.ru

Sabirova D.R. ― resident doctor of Obstetrics and Gynecology Department №1, tel. +7-987-297-00-87, e-mail: dianochka434@gmail.com

TRALI syndrome is a complication relation to transfusion. It is manifested with hypoxia and non-cardiogenic lung edema, usually 6 hours after the blood components transfusion. The pathogenesis of TRALI is related to the anti-leukocyte antibodies. There are several hypotheses of its development. The final pathogenic element of the syndrome is the sharp increase of lung capillary permeability leading to the lung edema. The techniques used for treatment include oxygen therapy and symptomatic treatment. In harder cases it is appropriate to use the invasive auxiliary lung ventilation with constant positive pressure and inspiratory maintenance with pressure. About 70% of the patients need intubation and mechanical lung ventilation. The observation of TRALI syndrome are presented in women patients after blood components transfusion.

Key words: transfusion-related acute lung injury (TRALI), anti-leukocyte antibodies, non-cardiogenic lung edema.

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