E.V. SINEOK, I.V. MALOV, I.V. VLASOV

Samara State Medical University, 89 Chapayevskaya Str., Samara, Russian Federation, 443099

  Sineok E.V. — Cand. Med. Sc., Assistant Lecturer of the Department of Eye Diseases, tel. (846) 333-01-56, +7-927-603-32-38, e-mail: jenny.sineok@mail.ru

Malov I.V. — D. Med. Sc., Head of the Department of Eye Diseases, tel. (846) 333-01-56, e-mail: ivmsamara@gmail.com

Vlasov I.V. — D. Med. Sc., Professor of the Department of Neurology and Neurosurgery, tel. (846) 333-01-56, e-mail: sams99@inbox.ru

The article presents the results of traditional ophthalmic research of 317 patients (622 eyes) with demyelinating diseases. The evaluation of the reliability of the study was performed by calculation of sensitivity (Se) and specificity (Sp) of perimetry method. Basing on the obtained data, ROC-analysis (Receiver Operator Characteristic) was carried out, ROC curves were constructed and the area under the curve AUC (Area Under Curve) was calculated.

Key words: demyelinating diseases, perimetry, ROC-analysis.

REFERENCES

1. Sineok E.V. Opticheskaya kogerentnaya tomografiya setchatki v ranney diagnostike neyrodegenerativnykh izmeneniy pri demieliniziruyushchikh zabolevaniyakh: avtoref. dis. … kand. med. nauk [Optical coherent tomography of the retina in the early diagnosis of neurodegenerative changes in demyelinating diseases. Synopsis of dis. PhD med. sciences]. Samara, 2015. 171 p., 43 il.
2. Karnaukh V.N. Invalidization and ability to work of patients with multiple sclerosis. Ekspertiza i reabilitatsiya, 2010, no. 4, p. 11 (in Russ.).
3. Poverennova I.E., Vlasov Ya.V., Khivintseva E.V., Zakharov A.V., Kuznetsova N.I. Rasseyannyy skleroz: uchebnoe posobie dlya poslevuzovskogo obrazovaniya [Multiple sclerosis: a manual for postgraduate education ]. Samara: SamGMU, 2009. 56 p.
4. Svirin A.V., Kiyko Yu.I., Obruch B.V. et al. Spectral optical coherence tomography: principles and possibilities of the method. Klinicheskaya oftal’mologiya, 2009, vol. 10, no. 2, pp. 50-52 (in Russ.).
5. Zavalishin I.A., Piradova M.A., Boyko A.N. et al. Autoimmunnye zabolevaniya v nevrologii [Autoimmune diseases in neurology]. Moscow: Zdorov’e cheloveka, 2014. 400 p.
6. Chan J.W. Early diagnosis, monitoring, and treatment of optic neuritis. Neurologist, 2012, vol. 18, no. 1, pp. 23-31.
7. Oreja-Guevara C., Noval S., Alvarez-Linera J. et al.Clinically isolated syndromes suggestive of multiple sclerosis: an optical coherence tomography study. PLoS One, 2012, vol. 7, no. 3, p. e33907.