L.I. MALTSEVA, Yu.V. GARIFULLOVA

Kazan State Medical Academy, 36 Butlerov St., Kazan, Russian Federation, 420012 

Maltseva L.I. ― D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology №1, tel. (843) 236-46-41, e-mail: laramalc@mail.ru

Garifullova Yu.V. ― postgraduate student of the Department of Obstetrics and Gynecology №1, tel. +7-919-637-22-33, e-mail: gamgg@yandex.ru 

To reveal the connection between vitamin D blood level, clinical presentation of the disease and features of hormone status f women with various forms of mastopathy, we have examined 72 women, 42 of them with diffuse and nodal forms and 30 healthy women as a control group. Examination included physical examination, ultrasound investigation of mammary glands and mammography. The initial level of vitamin D in blood serum was found. The content of estradiol, progesterone and prolactin in blood, as well as the level of vitamin D-binding protein, were measured by IFA technique. The reduction of vitamin D blood level was determined in 88.5% patients with various forms of mastopathy, the expressed deficit was found in 47.6% of the patients. The level of vitamin D blood level reduction correlated with the severity of clinical symptoms, changes in the mammary glands structure, according to ultrasound investigation, and higher levels of prolactin in patients compared to healthy women.

Key words: mastopathy, vitamin D, vitamin D-binding protein, prolactin.

REFERENCES

1. Kravchenko E.N., Ozherel’eva M.A. Status of breast and gynecological diseases (literature review). Mat’ i ditya v Kuzbasse, 2014, no. 2, pp. 19-23 (in Russ.).

2. Tagieva T.T. Risk factors for breast diseases. Vestnik RONTs im. N.N. Blokhina RAMN, 2007, vol. 18, no. 2, pp. 68-73 (in Russ.).

3. Trubnikova L.I., Tikhonova N.Yu., Savinova N.A. A comprehensive examination and treatment of women with diseases of the mammary glands and genitals. Ul’yanovskiy mediko-biologicheskiy zhurnal, 2013, no. 3, pp. 65-75 (in Russ.).

4. Prakticheskaya mammologiya, pod red. M.I. Davydova, V.P. Letyagina [Practical mammalogy. Ed. by M.I. Davydov, V.P. Letyagina]. Moscow: Prakticheskaya meditsina, 2007.

5. Garland C.F., Gorham E.D., Mohr S.B., Grant W.B., Giovannucci E.L., Lipkin M. et al. Vitamin D and prevention of breast cancer: Pooled analysis. J. Steroid Biochem. Mol. Biol, 2007, 103, pp. 708-711.

6. Rejnmarka L., Tietzeb A., Vestergaarda P., Buhlc L., Lehbrinkb M., Heickendorffd L., Mosekildea L. Reduced pre-diagnostic 25-hydroxyvitamin D levels in women with breast cancer. Abstracts. Bone, 2009, 44, pp. S162-S167.

7. Kay W. Vitamin D and breast cancer risk. Colston Best Practice & Research Clinical Endocrinology & Metabolism, 2008, vol. 22, no. 4, pp. 587-599.

8. Nair Lopes, Bárbara Sousa, Diana Martins, Alterations in vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions vitamin D pathways unbalanced in breast lesions. BMC Cancer, 2010, 10, p. 483.

9. Bischoff-Ferrari H.A., Burckhardt P., Quack-Loetscher K., Gerber B., I’Allemand D., Laimbacher J., Bachmann M. and Rizzoli R. Vitamin D deficiency: Evidence, safety, and recommendations for the Swiss population. Report written by a group of experts on behalf of the Federal Commission for Nutrition (FCN), 2012, available at: http://www.iccidd.org/p142000804.html.3

10. Dawson-Hughes B., Mithal A., Bonjour J.P. et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int, 2010, 21 (7), pp. 1151-4.

11. Garland F., Garland C., Gorham E., Young J. Jr. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev. Med, 1990, 19, pp. 614-622.

12. Raimondi S., Johansson H., Maisonneuve P., Gandini S. Review and metaanalysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis, 2009, 30, pp. 1170-1180.

13. Tang C., Chen N., Wu M., Yuan H., Du Y., Fok I. Polymorphism of vitamin D receptor gene contributes to breast cancer susceptibility: a meta-analysis. Breast Cancer Res. Treat, 2009, 117, pp. 391-399.