M.A. SHALENKOVA, E.T. MANYUKOVA, Z.D. MIKHAILOVA, P.F. KLIMKIN

Municipal Clinical Hospital № 38, 22 Сhernyshevskogo St., Nizhniy Novgorod, Russian Federation 603000

Shalenkova M.A. — D. Med. Sc., consultant, tel. +7-920-050-63-53, e-mail: mshalenkova@yandex.ru

Manyukova E.T. — doctor, tel. +7-930-803-48-88, e-mail: elwira.manyukova@yandex.ru

Mikhailova Z.D. — Cand. Med. Sc., consultant, tel. +7-930-803-48-88, e-mail: zinaida.mihailowa@yandex.ru

Klimkin P.F. — doctor, tel. +7-920-058-19-86, e-mail: climckin2009@yandex.ru

The purpose of the study is to determine the role of immuno-inflamatory reactions in foreseeing the possible ACS development during the 1-3 days of the hospital period. There has been studied the content of C-reactive protein (hs-CRP), natriuretic peptide (NTproBNP), interleukin-6 (IL-6), interleukin-10 (IL-10) in the blood and IL-6, IL-10 in the saliva of the patients with acute coronary syndrome (ACS) (n=173) and stable angina (SA) (n=57). There has been identified a high hs-CRР and IL-6 level in the blood of the patients suffering from ACS in comparison with SA patients. A higher content of IL-10 in the blood has been revealed in patients with unstable angina and wave myocardial infarction (non-Q MI), and NTproBNP — in patients with Q-wave myocardial infarction (QMI). Development of complications in ACS patients was preceded by a higher content of IL-6 and IL-10 in their saliva, in comparison with the blood. The obtained results can be used as supplementary diagnostic criteria, which allow to predict the development of cardiovascular complications in ACS patients in the hospital period.

Key words: acute coronary syndrome, complications, С-reactive protein, natriuretic peptide, interleukin-6, interleukin-10.

REFERENCES

1. Shal’nova S.A., Deev A.D. Mortality trends in Russia at the beginning of the XXI century (according to official statistics). Kardiovaskulyarnaya terapiya i profilaktika, 2011, no. 6, pp. 5-11 (in Russ.).

2. Obraztsow W.P., Straschesko N.D. Zur Kenntis der Thrombose der Koronararterien des Herzens. Z Klin Med., 1910, no. 71, pp. 116-125.

3. Demograficheskiy ezhegodnik Rossii. 2010: Stat. sb. [Demographic Yearbook of Russia. 2010: Stat. Sat]. Moscow, 2010, Rosstat. 525 p.

4. Roger V.L., Go A.S., Lloyd-Jones D.M. et al. Heart Disease and Stroke Statistics 2012. American Heart Association Circulation, 2012, no. 125, pp. 2-220.

5. Salakhova G.M. Kliniko-diagnosticheskoe znachenie markerov vospaleniya pri ishemicheskoy bolezni serdtsa: avtoref. dis. … kand. med. nauk [Clinical and diagnostic value of markers of inflammation in coronary artery disease. Synopsis of dis. PhD med. sci]. Chelyabinsk, 2009. 23 p.

6. Ragino Yu.I., Kuimov A.D., Polonskaya Ya.V. Dynamics of changes in inflammatory oxidative biomarkers in the blood in acute coronary syndrome. Kardiologiya, 2012, no. 2, pp. 18-22 (in Russ.).

7. Zykov K.A., Nuraliev E.Yu., Kaznacheeva E.I. et al. Dynamics of inflammation in patients with acute coronary syndrome and stable angina. Message II. Biochemical, immunological and clinical aspects. Kardiologicheskiy vestnik, 2011, no. 1, pp. 23-32 (in Russ.).

8. Shreyder E.V., Shakhnovich R.M., Kaznacheeva E.I. et al. Prognostic value of inflammatory markers and NT-proBNP in different variants of the treatment of patients with acute coronary syndrome. Kardiologicheskiy vestnik, 2008, no. 2, pp. 44-53 (in Russ.).

9. Kukharchuk V.V., Zykov K.A., Masenko V.P. et al. Dynamics of inflammation in patients with acute coronary syndrome and patients with stable angina. Message 1. Biochemical and immunological aspects. Kardiologicheskiy vestnik, 2007, no. 2, pp. 48-55 (in Russ.).

10. Oganov R.G., Zairian N.E., Zakirova A.N. et al. Immunoinflammatory response in acute coronary syndrome. Ratsional’naya farmakoterapiya v kardiologii, 2007, no. 5, pp. 15-19 (in Russ.).

11. Liping H., Xinyi T., Wenhua L. Early C-reactive protein in the prediction of long-term oucomes after acute coronary syndrome: a meta-analisys of longitudinal studies. Heart, 2010, no. 96, pp. 339-346.

12. Novichikhina I.A. Prognozirovanie techeniya ostrogo infarkta miokarda s ispol’zovaniem pokazateley gemodinamiki i biokhimicheskikh parametrov krovi i slyuny: avtoref. dis. … kand. med. nauk [Prognosis of acute myocardial infarction with hemodynamic and biochemical parameters of blood and saliva. Synopsis of dis. PhD med. sci]. Moscow, 2002. 21 p.

13. Dolbin I.V. Kardial’nyy sindrom Kh: osobennosti patogeneza i lecheniya: avtoref. dis. … d-r med. nauk [Cardiac syndrome X: pathogenesis and treatment characteristics. Synopsis of dis. PhD med. sci]. Nizhniy Novgorod, 2011. 41 p.

14. Goryacheva O.G. Vzaimosvyaz’ pokazateley antioksidantnoy zashchity i kliniko-gemodinamicheskogo statusa pri infarkte miokarda: avtoref. dis. … kand. med. nauk [Correlation of antioxidant protection and clinical hemodynamic status in myocardial infarction. Synopsis of dis. PhD med. sci]. Perm, 2011. 24 p.

15. Byuyul’ A., Tsefel’ P. SPSS: iskusstvo obrabotki informatsii. Platinum Edition. Per. s nem. [SPSS: art information processing. Platinum Edition. Lane with it]. Saint Petersburg: DiaSoftYuP, 2005. 608 p.

16. Fushtey I.M., Podsevakhina S.P., Lashkul Z.V. Diagnostic value of pro-and anti-inflammatory cytokines in patients with different clinical forms of acute coronary syndrome. Meditsina neotlozhnykh sostoyaniy, 2007, no. 6, pp. 83-94 (in Russ.).

17. Kopitsa N.P., Litvin E.I. Interleukin-10 and C-reactive protein as a prognostic markers repeated vascular events after acute coronary syndrome. Visnik Kharkivs’kogo natsional’nogo universitetu imeni V.N. Karazina, 2010, no. 898 (in Russ.).