O.V. LAPSHINA^1,2, E.A. ANTIPENKO², K.N. KONTORSHCHIKOVA², A.V. BARANOVA³, D.V. SEDYSHEV¹, A.V. GUSTOV²

¹Nizhny Novgorod Regional Clinical hospital named after N.A. Semashko, 190 Rodionov Str., Nizhniy Novgorod, Russian Federation, 603126

²Nizhny Novgorod State Medical Academy, 10/1 Minin Square, Nizhny Novgorod, Russian Federation, 603005

³National Research Nizhny Novgorod State University named after N.I. Lobachevsky, 23 Gagarin Pr., Nizhny Novgorod, Russian Federation, 603022

Lapshina O.V. ― doctor-neurologist of the 1^st Neurology Department, correspondence postgraduate student of the Department of Neurology, Psychiatry and Narcology, tel. +7-908-232-11-31, e-mail: olga-med@list.ru

Antipenko E.A. ― D. Med. Sc., Associate Professor of the Department of Neurology, Psychiatry and Narcology, tel. +7-951-919-41-96, e-mail: antipenkoea@gmail.com

Sedyshev D.V. ― Cand. Med. Sc., Head of the 1^st Neurology Department, tel. +7-910-141-39-51, e-mail: Doc_neuro@mail.ru

Gustov A.V. ― D. Med. Sc., Professor, Head of the Department of Neurology, Psychiatry and Narcology, tel. +7-910-873-93-57, e-mail: gustovava@mail.ru

Kontorshchikova K.N. ― D. Med. Sc., Professor, Head of the Department of Clinical Laboratory Diagnostics, tel. +7-903-055-71-99, e-mail: kontclin@mail.ru

Baranova A.V. ― 4^th-year student of the Institute of Biology and Biomedicine, tel. +7-960-180-16-73, e-mail: divitty@yandex.ru

Activation of free radical oxidation, as a typical pathological process, is an important link in the pathogenesis of several autoimmune diseases, including myasthenia gravis. In the study of oxidative homeostasis in 20 patients with myasthenia gravis, there were changes of oxidative homeostasis in patients with myasthenia as compared to healthy volunteers. The dynamics was analyzed of indicators of oxidation processes and antioxidant activity included into the therapeutic complex of ozone therapy. There was a positive influence of ozone therapy on the processes of free radical oxidation, which makes ozone therapy pathogenetically substantiated method of treatment of myasthenia gravis.

Key words: myasthenia gravis, ozone therapy, lipid peroxidation.

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