The importance of vitamin D for women’s health and reproductive potential
L.I. MALTSEVA, A.S. POLUKEEVA, Yu.V. GARIFULLOVA
Kazan State Medical Academy, 36 Butlerov St., Kazan, Russian Federation, 420012
Maltseva L.I. — D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology № 1, tel. +7-905-314-40-51, e-mail: laramalc@mail.ru
Polukeeva A.S. — postgraduate student of the Department of Obstetrics and Gynecology № 1, tel. +7-919-681-22-77, e-mail: nastiax86@mail.ru
Garifullova Yu.V. — external doctorate student of the Department of Obstetrics and Gynecology № 1, tel. +7-919-637-22-33, e-mail: gamgg@yandex.ru
The article introduces literature data concerning the current understanding of the role of vitamin D in the implementation of its non-classical effects associated with a number of somatic pathology and dysfunction of the reproductive system. There are described the results of the studies which prove the effect of vitamin D deficiency on the development of obesity, insulin resistance, hypertension states, cancer of various localization. Reduced availability of vitamin D is associated with the endometrial disease, metabolic disturbances in case of polycystic ovarian disease and IVF failures. Vitamin D deficiency is negative during pregnancy. The article describes convincing data on the effects of vitamin D deficiency on the development of pre-eclampsia, bacterial vaginosis, preterm delivery in women.
Key words: reproductive health, pathology, vitamin D.
REFERENCES
- Lund J., DeLuca H.F. Biologically active metabolite of vitamin D3 from bone, liver, and blood serum. J Lipid Res., 1966;6:739-744.
- Rajakumar K. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics, 2003;112: e132-e135.
- Christakos S., Dhawan P., Benn B., Porta A., Hediger M., Oh G.T., Jeung E.B., Zhong Y., Ajibade D., Dhawan K., Joshi S. Vitamin D: molecular mechanism of action. Ann N Y Acad Sci., 2007;1116:340-348.
- Reichel H., Koeffler H.P., Norman A.W. The role of vitamin D endocrine system in health and disease. N Engl J Med., 1989;320:980-991.
- Walters M.R. Newly identified actions of the vitamin D endocrine system. Endocr Rev., 1992;13:719-763.
- Christakos S. et al. Vitamin D: metabolism. Endocrinol Metab Clin North Am., 2010;39(2):243-53.
- Christakos S., Raval-Pandya M., Wernyj R.P., Yang W. Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3. Biochem J., 1996; 316:361-371.
- Merewood A., Mehta S.D., Chen T.C., Bauchner H., Holick M.F. Association between vitamin D deficiency and primary cesarean section. Journal of Clinical Endocrinology and Metabolism, 2009; 94;3;940-945.
- Dambakher M.A., Shakht E. Osteoporosis and active metabolites of vitamin D: the thoughts that come to mind. Eular Publishers, Basel 1996;139 (in Russ.).
- Erben R.G., Soegiarto D.W., Weber K., Zeitz U., Lieberherr M., Gniadecki R., Möller G., Adamski J., Balling R. Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Mol Endocrinol., 2002;16:1524-1537.
- Christakos S., Barletta F., Huening M., Dhawan P., Liu Y., Porta A., Peng X. Vitamin D target proteins: function and regulation. J Cell Biochem., 2003;88:238-244.
- Kinuta K., Tanaka H., Moriwake T., Aya K., Kato S., Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology, 2000;141:1317-1324.
- Looker A.C., Pfeiffer C.M., Lacher D.A., Schleicher R.L., Picciano M.F., Yetley E.A. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr 2008;88:1519-1527.
- Kovacs C.S. Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. Am J Clin Nutr., 2008;88:520S-528S.
- Alemzadeh R., Kichler J., Babar G., Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism, 2008;57:183-191.
- Diehl J.W., Chiu M.W. Effects of ambient sunlight and photoprotection on vitamin D status. Dermatol. Ther., 2010;23:48-60.
- Bell N.H., Epstein S., Greene A., Shary J., Oexmann M.J., Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin. Invest., 1988;76:370-373.
- Wortsman J., Matsuoka L.Y., Chen T.C., Lu Z., Holick M.F. Decreased bioavailability of vitamin D in obesity. Am. J Clin. Nutr. 2000;72:690-693.
- Foss Y.J. Vitamin D deficiency is the cause of common obesity. Med Hypotheses, 2009;72:314-321.
- Matsunuma A., Horiuchi N. Leptin attenuates gene expression for renal 25-hydroxyvitamin D3-1alpha-hydroxylase in mice via the long form of the leptin receptor. Arch Biochem Biophys., 2007;463:118-127.
- Shvarts G.Ya. Deficiency of vitamin D and its pharmacological correction. Russkiy meditsinskiy zhurnal, 2009, no. 7 (in Russ.).
- Garland F.C., Garland C.F., Gorham E.D., Young J.F. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med., 1990;19:614-22.
- Garland C., Shekelle R.B., Barrett-Connor E., Criqui M.H., Rossof A.H., Oglesby P. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet, 1985;9:307-9.
- Hanchette C.L., Schwartz G.G. Geographic patterns of prostate cancer mortality: evidence for a protective effect of ultraviolet radiation. Cancer, 1992;70:2861-9.
- Tuohimaa P., Tenkanen L., Ahonen M., Lumme S., Jellum E., Hallmans G. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer, 2004;108:104-8.
- Apperly F.L. The relation of solar radiation to cancer mortality in North America, Cancer Res., 1941;1:191-5.
- Hypponen E., Laara E., Jarvelin M.-R., Virtanen S.M. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet, 2001;358:1500-3.
- Merlino L.A., Curtis J., Mikuls T.R., Cerhan J.R., Criswell L.A., Saag K.G. Vitamin D intake is inversely associated with rheumatoid arthritis. Arthritis Rheum, 2004;50:72-7.
- Tanaka H., Abe E., Miyaura C. et al. 1,25-Dihydroxycholeciferol and human myeloid leukemia cell line (HL-60): the presence of cytosol receptor and induction of differentiation. Biochem J., 1982;204:713-9.
- Cross H.S., Bareis P., Hofer H., Bischof M.G., Bajna E., Kriwanek S. 25-Hydroxyvitamin D3-1α-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids, 2001;66;287-92.
- Bodnar L.M. et al. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr., 2007;137;2;447-452.
- V.A. Holmes et al. Vitamin D deficiency and insufficiency in pregnant women: a longitudinal stud. Br J Nutr., 2009;102;6;876-881.
- Li H.W., Brereton R.E., Anderson R.A., Wallace A.M., Ho C.K. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism, 2011;60;1475-1481.
- Kotsa K., Yavropoulou M.P., Anastasiou O., Yovos J.G. Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertility and Sterility, 2009;92;3;1053-1058.
- Viganò P., Lattuada D., Mangioni S., Ermellino L., Vignali M., Caporizzo E., Panina-Bordignon P., Besozzi M., Di lasio A.M. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. Journal of Molecular Endocrinology, 2006;36;415-424.
- Agic A., Xu H., Altgassen C., Noack F., Wolfler M.M., Diedrich K., Friedrich M., Taylor R.N., Hornung D. Relative expression of 1,25-dihydroxyvitamin D3receptor, vitamin D 1α-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Reproductive Sciences, 2007;14;486-497.
- Barrera D., Avila E., Hernández G., Méndez I., González L., Halhali A., Larrea F., Morales A., Díaz L. Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts. Reproductive Biology and Endocrinology, 2008;6;3.
- Barrera D., Avila E., Hernández G., Halhali A., Biruete B., Larrea F., Díaz L. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. Journal of Steroid Biochemistry and Molecular Biology, 2007;103;529-532.
- Tuan R.S., Moore C.J., Brittingham J.W., Kirwin J.J., Akins R.E., Wong M. In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. Journal of Cell Science, 1991;98;333-342.
- Stephanou A., Ross R., Handwerger S. Regulation of human placental lactogen expression by 1,25-dihydroxyvitamin D3. Endocrinology, 1994.
- Du H., GS, Lalwani S.I., Taylor H.S. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Molecular Endocrinology, 2005;19;2222-2233.
- Bagot C.N., Troy P.J., Taylor H.S. Alteration of maternal Hoxa10 expression by in vivo gene transfection affects implantation. Gene Therapy, 2000;7;1378-1384.
- Shand A.W., Nassar N., Von Dadelszen P., Innis S.M., Green T.J. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 2010;117;13;1593-1598.
- Bodnar L.M., Simhan H.N. The prevalence of preterm birth and season of conception. Paediatric and Perinatal Epidemiology, 2008;22;6;538-545.
- Hensel K.J., Randis T.M., Gelber S.E., Ratner A.J. Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis. American Journal of Obstetrics and Gynecology, 2011;204;1; 41.
- Zhang C. et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One, 2008;3;11;art. no. e3753.
- Bodnar L.M., Catov J.M., Simhan H.N. Maternal vitamin D deficiency increases the risk of preeclampsia. Journal of Clinical Endocrinology and Metabolism, 2007;92;9;3517-3522.
- Haugen M., Brantsaeter A.L., Trogstad L. et al. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology, 2009;20;5;720-726.
- Baker A.M., Haeri S., Camargo C.A., Stuebe A.M., Boggess K.A. First-trimester maternal vitamin D status and risk of gestational diabetes (GDM): A nested case-control study. Diabetes/Metabolism Research and Reviews, 2012;28;2;164-168.
- Makgoba M. et al. First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care, 2011;34(5):1091-3.
- Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin. North. Am., 2010;39;2;365-379.
- Díaz L., Noyolaartínez N., Barrera D., Hernández G., Avila E., Halhali A., Larrea F. Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts. J. Reprod. Immunol., 2009;81;17-24.
- Hollis B.W., Wagner C.L. Randomized controlled trials to determine the safety of vitamin D supplementation during pregnancy and lactation. Fourteenth workshop on vitamin D. Brugee, Belgium, 2009;134.
- Shibata M. et al. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner. Metab., 2011;29(5):615-20.
- Bodnar L.M. et al. Maternal vitamin D deficientcy is Associated with bacterial vaginosis in the first trimestr of pregnancy. J. Nutr. 2009;139;6;1157-11618.