The health status of children conceivedwith assisted reproductive technologies
E.M. MIKHEEVA¹, N.I. PENKINA²
¹The First Republican Clinical Hospital, 57 Votkinskoye Shosse, Izhevsk, Russian Federation, 426039
²Izhevsk State Medical Academy, 281 Kommunarov St., Izhevsk, Russian Federation, 426034
Mikheeva E.M. — postgraduate student of the Department of Pediatrics and Neonatology, neonatologist, tel. +7-906-819-92-56, e-mail: alena-sher@yandex.ru
Penkina N.I. — D. Med. Sc., Professor of the Department of Pediatrics and Neonatology, tel. +7-922-689-13-67, e-mail: dpenkina@yandex.ru
In the recent decades the number of children conceived with assisted reproductive technology (ART) is constantly growing, and is now about 4%. The recent scientific research is controversial and requires further investigation of the health of children born with ART. Some authors mark the high risk of infectious diseases, congenital malformation and chromosome abnormalities, infantile cerebral paralysis, perinatal pathologies, intrauterine growth retardation and prematurity in such children. Other researchers present results proving that the children born with artificial and natural impregnation have no differences in somatic health and psychoemotional development.
Key words: assisted reproductive technologies, in vitro fertilization, infertility, children’s health.
REFERENCES
1. Kulakov V.I., Savel’eva G.M., Manukhin I.B. Ginekologiya. Natsional’noe rukovodstvo [Gynecology. National leadership]. Moscow: Geotar-media, 2009. 1088 p.
2. Adamyan L.V. Status and prospects of reproductive health in Russia. Sovremennye tekhnologii v diagnostike i lechenii ginekologicheskikh zabolevaniy, 2007, pp. 5-19 (in Russ.).
3. Vayena E., Rowe P., Griffin P. Current practices and controversies in assisted reproduction: report of a WHO meeting. Geneva, World Health Organization, 2002.
4. Korsak V.S., Smirnova A.A., Shurygina O.V. Register ART centers in Russia. Report 2011. Problemy reproduktsii, 2013, no. 5, pp. 7-16 (in Russ.).
5. De Mouzon J., Goossens V., Bhattacharya S., Castilla J.et al. European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE): Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Human Reproduction, 2010, 25:1851-62.
6. Koivurova S., HartikainenA.L., Sovio U., Gissler M., Hemminki E., JarvelinM.R. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod., 2003;18: 2328 -2336.
7. Squires J., Kaplan P. Developmental Outcomes of Children Born After Assisted Reproductive Technologies. Infants andyoung children, 2007, vol. 20, no. 1, pp. 2-10.
8. Ericson A., Källén B. Congenital malformations in infants born after IVF: A population-based study. Human Reproduction, 2001; 16:504-9.
9. Pinborg A., Loft A., Schmidt.L, Greisen G.et al. Neurological sequelae in twins born after assisted conception: controlled national cohort study. BMJ, 2004; 329:311.
10. Rimm A., Katayama A., Diaz M., Katayama K. A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children. J. Assist. Reprod. Genet., 2004; 21:437-43.
11. Hansen M., Kurinczuk J., Bower C., Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N. Engl. J. Med, 2002;346:725-30.
12. Zhu J., Hvidtjshrn D., Basso O., Obel C. et al. Parental infertility and cerebralpalsy in children. Human Reproduction, 2010, vol. 25, no. 12, pp. 3142-3145.
13. Klemetti R., Sevon T., Gissler M., Hemminki E. Health of children born as a result of in vitro fertilization. Pediatrics, 2006; 118:1819-1827.
14. Lie R., Lyngstadaas A., Bakketeig L., Jacobsen G. et al. Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis. Int. J. Epidemiol, 2005,34:696-701.
15. Tararbit K., Lelong N., Thieulin A., Houyel L.et al. The risk for four specific congenital heart defects associated with assisted reproductive techniques: a population-based evaluation. Human Reproduction, 2013, vol. 28, pp. 367-374.
16. Kai C.M., Main K.M., Andersen A.N., Loft A., Chellakooty M., Skakkebaek N.E., Juul A. Serum insulin-like growth factor-I (IGF-I) and growth in childrenborn after assisted reproduction. J. Clin. Endocrinol. Metab., 2006;91:4352-4360.
17. Kallen B., Finnstrum O., Nygren K., Olausson P. In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods. Birth Defects Res A Clin Mol Teratol, 2005;73:162-9.
18. Wood H., Babineau D., Gearhart J. In vitro fertilization and the cloacal / bladder exstrophy-epispadias complex: a continuing association. J. Pediatr. Urol., 2007;3:305-10.
19. Funke S., Flach E., Kiss I., Sándor J. et al.: Male reproductive tract abnormalities: more common after assisted reproduction? Early Hum. Dev., 2010; 86:547-50.
20. ZwinkN., Jenetzky E., Schmiedeke E., Schmidt D. et al. Assisted reproductive techniques and the risk of anorectal malformations: a German case-control study. Orphanet Journal of Rare Diseases, 2012, 7:65, available at: http://www.ojrd.com/content/7/1/65
21. Wennerholm U.-B., Albertsson-Wikland K., Bergh C., Hamberger L. et al. Postnatal growth and health in children born after cryopreservation as embryos. Lancet, 1998; 351:1085-90.
22. DeBaun M., Niemitz E., Feinberg A..Association of in vitro fertilization with Beckwith-Wiedemann Syndrome and epigenetic alterations of LIT1 and H19. Am J. Hum.Genet., 2003;72:156-60.
25. Sakka S., Loutradis D., Kanaka-Gantenbein C., Margeli A. et al. Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization. Fertil. Steril., 2010;94:1693-1699.
26. Ceelen M., van Weissenbruch M., Roos J., Vermeiden J. et al. Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J. Clin. Endocrinol. Metab., 2007;92:3417-3423.
27. Sutcliffe A., D’Souza S., Cadman J., Richards B.et al. Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos. Human Reproduction, 1995, vol. 10, pp. 3332-3337.
28. Ludwig M., Katalinic A., Gro S., Sutcliffe A.et al. Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. J. Med. Genet., 2005;42:289-291.
29. Nelissen E., van Montfoort A., Dumoulin J., Evers J. Epigenetics and the placenta. Human Reproduction Update, 2011;17:397-417.
30. Belva F., Henriet S., Van den Abbeel E., Camus M. et al. Neonatal outcome of 937 children born after transfer of cryopreserved embryos obtained by ICSI and IVF and comparison with outcome data of fresh ICSI and IVF cycles. Human Reproduction, 2008;23:2227-2238.
31. Pandey S., Shetty A., Hamilton M., Bhattacharya S., Maheshwari A. Obstetric and perinatal outcomes in singleton pregnnancies resulting from IVF/ ICSI: a systematic review and metaanalysis. Hum Reprod Update, 2012;18:5:485 -503.
32. Kallen B., Finnstrom O., Lindam A., Nilsson E. et al. Cancer risk in children and young adults conceived by in vitro fertilization. Pediatrics, 2010;126:270-276.
33. Marees T., Dommering C., Imhof S., Kors W. et al. Incidence of retinoblastoma in Dutch children conceived by IVF: an expanded study. Human Reproduction, 2009;24:3220-3224.
34. Leunens L., Celestin-Westreich S., Bonduelle M., Liebaers I.et al. Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children. Human Reproduction, 2008;23,1:105-111.
35. Ludwig A.K., Katalinic A., Thyen U., Sutcliffe A.G., Diedrich K., Ludwig M. Physical healthat 5.5 years of age of term-born singletons after intracytoplasmic sperm injection:results of a prospective, controlled, single-blinded study. Fertil Steril, 2009;91:115-124.