G.G. YAPHAROVA^1,2, A.D. MILITSKOVA², A.A. SHULMAN¹, K.N. SPIRIDONOVA², L.M. BIKTCHENTAEVA²

¹Republic Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

²Kazan (Volga Region) Federal University, 18 Kremlevskaya Str., Kazan, Russian Federation, 420008

 Yapharova G.G. ― Cand. Biol. Sc., Chief Researcher of the Scientific and Research Department, Senior Researcher of OpenLab «Motor neurorehabilitation» of the Institute of Fundamental Medicine and Biology, tel. +7-937-618-07-92, e-mail: gusadila@mail.ru

Militskova A.D. ― Junior Researcher of OpenLab «Motor neurorahabilitation» of the Institute of Fundamental Medicine and Biology, tel. +7-906-327-13-29, e-mail: fata.morgana2010@yandex.ru

Shulman A.A. ― Senior Researcher of the Scientific and Research Departament, tel. +7-917-395-35-02, e-mail: ani_07@mail.ru

Spiridonova K.N. ― Research Assistant of OpenLab «Motor neurorahabilitation» of the Institute of Fundamental Medicine and Biology, tel. +7-965-599-52-81, e-mail: ksenya1.618@gmail.com

Biktchentaeva L.M. ― Research Assistant of OpenLab «Motor neurorahabilitation» of the Institute of Fundamental Medicine and Biology, tel. +7-965-599-52-81, e-mail: leysanbm@mail.ru

 The article describes the possibilities of application of the method of percutaneous electric stimulation of the spinal cord to activate the motor functions of the lower extremities. Non-invasive transcutaneous electric stimulation of the spinal cord at Th11-12 vertebrae level in healthy people at rest induces a complex action potential in the distal muscles of the lower extremities and can serve as an alternative to the method of epidural stimulation. It is made clear that subthreshold transcranial magnetic stimulation affects corticospinal excitability and enhances spinal motor responses to percutaneous electric stimulation of the spinal cord.

Key words: spine cord, transcutaneous electric stimulation, transcranial magnetic stimulation.

REFERENCES

1. Gorodnichev R.M., Pivovarova E.A., Pukhov A. et al. Percutaneous electrical stimulation of the spinal cord: non-invasive way of activation of generators of pacing movements in humans. Fiziologiya cheloveka, 2012, vol. 38, no. 2, p. 46 (in Russ.).
2. Gerasimenko Y., Gorodnichev R., Moshonkina T. et al. Transcutaneous electrical spinal-cord stimulation in humans. Annals of Physical and Rehabilitation Med, 2015, vol. 58, no. 4, pp. 225-231.
3. Sayenko D.G., Angeli C., Harkema S.J. et al. Neuromodulation of evoked muscle potentials induced byepidural spinal-cord stimulation in paralyzed individuals. J. Neurophysiol, 2014, vol. 111, no. 5, pp. 1088-1099.
4. Ladenbauer J., Minassian K., Hofstoetter U.S. et al. Stimulation of the human lumbar spinal cord with implanted and surface electrodes: a computer simulation study. IEEE Trans. Neural. Syst. Rehabil. Eng, 2010, vol. 18, no. 6, pp. 637-654.
5. Knikou M. Transpinal and transcortical stimulation alter corticospinal excitability and increase spinal output. PLoS One, 2014, vol. 9, no. 7, pp. 1-12.
6. Hunter J.P., Ashby P. Segmental effects of epidural spinal cord stimulation in humans. J. Physiol. Lond, 1994, vol. 74, no. 3, pp. 407-419.
7. Roy F.D., Bosgra D., Stein R.B. Interaction of transcutaneous spinal stimulation and transcranial magnetic stimulation in human leg muscles. Exp. Brain Res, 2014, vol. 232, no. 6, pp. 1717-1728.
8. Gerasimenko Y.P., Lavrov I.A., Courtine G. et al. Spinal cord reflexes induced by epidural spinal cord stimulation in normal awake rats. J. Neurosci. Methods, 2006, vol. 157, no. 2, pp. 253-263.
9. Hofstoetter U.S, Minassian K., Hofer C.M. et al. Modification of reflex responses to lumbar posterior root stimulation by motor tasks in healthy subjects. Artif. Organs, 2008, vol. 32, no. 8, pp. 644-648.
10. Roy F.D., Gibson G., Stein R.B. Effect of percutaneous stimulation at different spinal levels on the activation of sensory and motor roots. Exp. Brain. Res, 2012, vol. 223, no. 2, pp. 281-289.