А.М. SAVRILOVA¹, А.V. КОSTERINA², I.S. МАRTYNKEVICH³

¹Republican Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

²Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012

³Russian Research Institute of Hematology and Transfusiology FMBA of Russia, 16 2^nd Sovetskaya St., Sankt-Petersburg, Russian Federation, 193024

Savrilova A.M. — haematologist of consultative polyclinic, tel. +7-905-312-63-09, e-mail: alsu-mindubaeva@yandex.ru

Коsterina A.V. — Assistant of the Department of Hospital Therapy, tel. +7-917-273-77-68, e-mail: avakost@mail.ru

Маrtynkevich I.S. — D. Biol. Sc., Head of the Laboratory of Molecular Genetics, tel. +7-911-225-38-03, e-mail: martynkevich.ira@mail.ru

The article presents a theoretical published data about combination of paroxysmal nocturnal hemoglobinuria and myeloproliferative disorders. A clinical case of a combination of these diseases, confirmed by laboratory methods (immunophenotyping of peripheral blood, bone marrow cytogenetic study, trephan biopsy). Translocation t (X; 7) is connected with high risk of transformation to acute leukemia.

Key words: paroxismal nocturnal hemoglobinuria, myeloproliferative disease, Jak2 V617F, translocation t (X;7).

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