A.R. KIRSHINA¹, A.A. KIRSHIN²  ¹Republic Сlinical Hospital, Kazan ²Republic Clinical Oncology Dispensary named after M.Z. Sigal, Kazan Contact details: Kirshina A.R. — gastroenterologist of the Gastroenterology Department Address: 138 A Orenburgskiy trakt, 420000 Kazan, Russian Federation, tel.: +7 (843) 231-21-78, e-mail: aygulraisovna@gmail.com Cholestatic liver diseases significantly impair quality of life and life expectancy, often necessitating liver transplantation. […]