E.A. ANTIPENKO¹, A.V. DERYUGINA², A.V. GUSTOV¹

¹Nizhny Novgorod State Medical Academy, 10/1 Minin and Pozharskiy Square, Nizhny Novgorod, Russian Federation, 603005

²Nizhny Novgorod National Research State University named after N.I. Lobachevsky, 23 Gagarin Pr., Nizhny Novgorod, Russian Federation, 603022

Antipenko E.A. ― D. Med. Sc., Associate Professor of the Department of Neurology, Psychiatry and Narcology, tel. +7-951-919-41-96, e-mail: antipenkoea@gmail.com

Deryugina A.V. ― Cand. Biol. Sc., Associate Professor of the Department of Physiology and Biochemistry of Humans and Animals

Gustov A.V. ― D. Med. Sc., Professor, Head of the Department of Neurology, Psychiatry and Narcology, tel. +7-910-873-93-57, e-mail: gustovava@mail.ru

Objective ― to clarify the mechanisms of the action of anti-stress antioxidant agent (mexidol) in patients with chronic cerebral ischemia.

Material and methods. Sixty-seven patients with chronic cerebral ischemia (TE stage II), 48 women and 19 men, mean age 48.2 years, were examined. The level of anxiety and depression, degree of autonomic imbalance, adaptive reactions of blood and functional properties of erythrocyte membranes, the level of average weight molecules in blood plasma were studied in order to assess the state of multilevel stress system. Therapeutic complexes consisted of standard therapy (vinpocetine and piracetam) and mexidol (10 ml intravenous drip 200 ml of physiological solution once a day every day for 10 days with subsequent transition to the oral ingestion of the drug (1 tablet (125 mg) 3 times a day for three months).

Results and conclusion. In group 1 treated with additional antioxidant mexidol, the more pronounced and prolonged positive effect on the clinical symptoms of TE was observed. There were the persistent decrease in the level of anxiety and reduction of autonomic imbalance in the main group. The dynamics of adaptive reactions of blood indicated the activation of the adrenal cortex. There was a decrease in the content of average weight molecules and recovery of the sorption capacity of red blood cells. The results indicate the multi-component multi-level stress-limiting effect of mexidol in patients with chronic cerebral ischemia stage II.

Key words: mexidol, chronic cerebral ischemia, treatment, stress.