G.V. BRATKO¹, A.N. TRUNOV^1,2, V.V. CHERNYKH¹

¹Novosibirsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution, 10 Kolkhidskaya Str., Novosibirsk, Russian Federation, 630096

²Scientific-research Institute of Experimental and Clinical Medicine, 2 Timakov Str., Novosibirsk, Russian Federation, 630117

Bratko G.V. — Cand. Med. Sc., Leading Researcher, e-mail: gbratko@yandex.ru

Trunov A.N. — D. Med. Sc., Professor, Deputy Director on Scientific Work, Head of the Immunology Laboratory of Scientific-research Institute of Experimental and Clinical Medicine, e-mail: trunov1963@yandex.ru

Chernykh V.V. — D. Med. Sc., Professor, Director, tel. (383) 341-96-37, e-mail: rimma@mntk.nsk.ru

The article analyzes ophthalmological data of 187 patients who underwent diagnostic testing in the Novosibirsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution with endocrine ophthalmopathy in the background of thyroid dysfunction. 9 cases of symptomatic ocular hypertension were identified, associated with high level of intraocular pressure, decrease of vision acuity in patients with severe endocrine ophthalmopathy against the background of decompensation of the underlying disease. Prescription of medication hypotensive therapy was justified, namely combination of carbonic anhydrase inhibitors (ICA) with β-blockers, which is associated with the presence of not only hypotensive effect in these drugs but also positive influence of ICA on microcirculation in the vessels supplying the optic nerve. This is significant for patients with decompensated forms of endocrine ophthalmopathy, with not only transient increase of intraocular pressure, but also signs of optic neuropathy in the absence of other signs of glaucoma, namely, changes in the anterior chamber angle, excavated glaucomatous optic nerve and consequent changes in the pattern of optical coherence tomography. All patients on the background of rationally chosen therapy received not only a significant reduction in intraocular pressure, but also the improvement of visual functions, on average, two weeks after the start of treatment.

Key words: endocrine ophthalmopathy, optic neuropathy, symptomatic ocular hypertension.

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