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  • Successful pregnancy in a comorbid patient nine months after heart transplantation

    Редактор | 2025, Practical medicine part 23 №2. 2025, СLINICAL OBSERVATIONS | 24 апреля, 2025

    A.V. KOLSANOVA1, I.S. KIYASHKO1, L.I. GULETSKAYA2, M.A. TSYGANOVA2, E.A. ZORINA2, I.E. DUFINETS1, O.I. LINEVA1, A.V. SOFINA1

     1Samara State Medical University, Samara

    2Samara Regional Clinical Cardiological Dispensary named after V.P. Polyakov, Samara

    Contact details:

    Kolsanova A.V. — MD (medicine), Associate Professor of the Department of Obstetrics and Gynecology

    Address: 89 Chapaevskaya St., 443099 Samara, Russian Federation, tel.: +7-937-980-54-19, e-mail: a.v.kazakova@samsmu.ru

    The purpose — to present a clinical observation of pregnancy and childbirth following heart transplantation.

    Material and methods. We describe a case of successful pregnancy in a patient with a heart transplant after dilated cardiomyopathy.

    Results. Pregnancy after heart transplantation poses a high risk for patients. We consider a case of successful first pregnancy in a 27-year-old patient in less than a year after heart transplantation. During pregnancy, cardiac graft dysfunction was noted, which was stopped by drug therapy correction. At 35–36 weeks, an emergency caesarean section was performed, and a healthy girl weighing 2750 g and 46 cm tall was born. The pregnancy had no complications.

    Conclusion. The clinical case demonstrates the possibility of a favorable pregnancy outcome, despite the high risk to the patient, provided dynamic clinical follow-up with an interdisciplinary approach is performed.

    Key words: pregnancy, heart transplantation, dilated cardiomyopathy.

    REFERENCES

    1. Nassif M.E., Kahn R. The impact of pregnancy on heart transplantation outcomes. J. Heart Lung Transplantation, 2021, vol. 40 (5), pp. 487–493.
    2. Javadi M. et al. Pregnancy after heart transplantation: A comprehensive review. Transplantation Rev, 2020, vol. 34 (1), pp. 30–37.
    3. Fitzgerald A. et al. Maternal and fetal outcomes in heart transplant recipients during pregnancy. J. Am. College Cardiol, 2019, vol. 73 (23), pp. 2920–2930.
    4. Wernovsky G., Rychik J. Heart transplantation and pregnancy: Current perspectives. Circul. J, 2022, vol. 86 (4), pp. 594–602.
    5. Obshcherossiyskaya obshchestvennaya organizatsiya transplantologov “Rossiyskoe transplantologicheskoe obshchestvo”. Klinicheskie rekomendatsii: transplantatsiya serdtsa, nalichie transplantirovannogo serdtsa, otmiranie i ottorzhenie transplantata serdtsa, 2023 [All-Russian public organization of transplantologists “Russian Transplant Society”. Clinical guidelines: heart transplantation, presence of a transplanted heart, death and rejection of a heart transplant, 2023]. 76 p.

    Метки: 2025, A.V. KOLSANOVA, A.V. SOFINA, dilated cardiomyopathy, E.A. ZORINA, heart transplantation, I.E. DUFINETS, I.S. KIYASHKO, L.I. GULETSKAYA, M.A. TSYGANOVA, O.I. LINEVA, Practical medicine part 23 №2. 2025, pregnancy

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