G.A. IGNATENKO, E.A. MAYLYAN, A.V. DUBOVAYA, A.A. KALUGA, A.N. GONCHAROV, E.A. SUBBOTINA

1. Gorky Donetsk National Medical University, Donetsk

  Contact details:

Maylyan E.A. — MD, Professor, Head of the Department of Microbiology, Virusology, Immunology and Allergology

Address: 16 prospekt Ilyicha, Donetsk, 283003, tel.: +7-949-320-31-70, е-mail: eduardmailyan095@gmail.com

 The purpose of the study was to evaluate the effects of interval hypoxic therapy in women with autoimmune thyroiditis (AIT) and hypothyroidism.

Material and methods. 136 women with newly diagnosed AIT and hypothyroidism were examined and divided into two equal groups. The first group received hormonal replacement therapy with levothyroxine sodium for 12 months. The second group received levothyroxine sodium in combination with interval hypoxic therapy.

Results. Levothyroxine sodium therapy in women with newly diagnosed AIT and hypothyroidism was associated with a further increase in the thyroperoxidase autoantibodies blood serum content (p < 0.001). The combination with hypoxic therapy led to the lower autoantibodies values than levothyroxine sodium monotherapy (p < 0.05). In addition, therapy with levothyroxine sodium was characterized by an increased need for medications (p < 0.001). Hypoxic therapy supplementation in AIT provided the medication dose stabilization.

Conclusions. It is appropriate to combine levothyroxine sodium with normobaric hypoxic therapy sessions (every 3 months for 10 days) in order to improve the effectiveness of autoimmune thyroiditis and hypothyroidism treatment in women.

Key words: women, autoimmune thyroiditis, hypothyroidism, hypoxic therapy.

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