V.M. DELYAGIN¹, O.A. SERDYUK¹, E.A. KOREPANOVA², T.A. MYAKISCHEVA²

¹Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 1 Samori Maschela St., Moscow, Russian Federation 117997

²Russian Scientific and Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation, 1 Ostrovityanova St., Moscow, Russian Federation 117997

Delyagin V.M. — D. Med. Sc., Professor, Head of Functional Diagnostics Department, Head of Clinical Physiology Department, tel. (495) 287-65-70 (int. 48-09), e-mail: delyagin-doktor@yandex.ru¹

Serdyuk O.A. — Physician of Functional Diagnostics Department, tel. (495) 287-65-70 (int. 48-09), e-mail:Olga.Serdyuk@fccho-moscow.ru¹

Korepanova E.A. — Cand. Sc. Biology, Assistant Professor of the Department of General and Medical Biophysics, tel. (495) 434-85-46, e-mail: rsmu@rsmu.ru²

Myakisheva T.A. — Diplomate of the Department of General and Medical Biophysics, tel. (495) 434-85-46, e-mail: rsmu@rsmu.ru² 

High-dose chemotherapy can cause loss of peripheral nerve, neuromuscular junction or muscle at any level. The features of indicants of electroneuromyography in 26 patients using various chemotherapy drugs (busulfan, fludarabine, vifend, vincristine, methotrexate and azathioprine) are investigated. Was obtained the reduction of the M-response, statistically significant difference in the speed of propagation of excitation along the nervesand F-response, that may indicate features of nerve damage in patients taking various chemotherapeutic drugs. Mixed type of damage could be the result of long-term treatment with different drugs and the influence of the oncological disease. The complex nature of toxic polyneuropathy in pediatric oncology induced by chemotherapeutic agents was traced, that can be explained by the peculiarities of the toxic influence of various drugs on the peripheral nervous system.

Key words: nerves, muscles, antineoplastic drugs, electroneuromyography.

REFERENCES

1. Politova E.A., Zavadenko N.N., Rumyantsev A.G. Neuromuscular disorders the treatment of acute leukemias and lymphomas (review). Onkogematologiya, 2013, no. 4, pp. 24-31 (in Russ.).

2. Daun H. Polyneuropathies as a diagnostic and therapeutic task. Fortschr. Med., 1977, Bd. 95, no. 14, pp. 935-943.

3. Au W., Mak W., Ho S. L., Leung S. Y., Kwong Y. L.: Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. Neurology, 2004, vol. 63, no. 3, pp. 588-589.

4. Bahl A., Chakrabarty B., Gulati S., Raju K., Raja A., Bakhshi S. Acute onset flaccid quadriparesis in pediatric non-Hodgkin lymphoma: vincristine induced or Guillain-Barre syndrome? Pediatr Blood Cancer., 2010, vol. 55, no. 6, pp. 1234-1235.

5. Brigo F., Balter R., Marradi P., Ferlisi M., Zaccaron A., Fiaschi A. et al. Vincristine-related neuropathy versus acute inflammatory demyelinating polyradiculoneuropathy in children with acute lymphoblastic leukemia. J. Child Neurol., 2012, vol. 27, no. 7, pp. 867-874.

6. Chang Y., Yoon H., Cho J., Sung K. Spinal MRI of vincristine neuropathy mimicking Guillain-Barre syndrome. Pediatr. Radiol., 2003, vol. 33, no. 11, pp. 791-793.

7. Darnel R., Posner J. Paraneoplasctic syndromes of the nervous system. New Engl. J. of Med., 2003, vol. 349, pp. 1543-1554.

8. Lanzkowsky Ph. Manual of pediatric hematology and oncology. Fouth Edition. Elseveir Inc., 2007. 832 p.

9. Aminoff M. Aminoffs Electrodiagnosis in Clinical Neurorogy. Sixth Edition, Elsevier Inc., 2012. Pp. 233-325.

10. Zenkov L.R., Ronkin M.A. Funktsional’naya diagnostika nervnykh bolezney [Functional diagnosis of nervous diseases]. Moscow: MEDpress-inform, 2011. Pp. 268-270.

11. Katts B. Nerv, myshtsa i sinaps [Nerve, muscle and synapse]. Moscow: Mir, 1968. Pp. 34-35.

12. Levin O.S. Polinevropatii: klinicheskoe rukovodstvo [Polyneuropathy: a clinical guide]. Moscow: Meditsinskoe informatsionnoe agentstvo, 2011. P. 496.

13. Nikolaev S.G., Bannikova I.B. Elektromiograficheskoe issledovanie v klinicheskoy praktike (metodiki, analiz, primenenie) [Electromyographic study in clinical practice (methodology, analysis, application]. Ivanovo: Ivanovskaya gosudarstvennaya meditsinskaya akademiya, 1998. P. 120.

14. Glants S. Mediko-biologicheskaya statistika [Biomedical Statistics]. Moscow: Praktika, 1999. P. 459.