R.T. NIGMATULLIN, B.R. MOTYGULLIN

Russian Eye and Plastic Surgery Center, Ufa, the Republic of Bashkortostan, Russian Federation

 Contact details:

Nigmatullin R.T. – D. Sc. (medicine), Deputy General Director for Science

Address: 67/1 Richard Sorge St., Ufa, the Republic of Bashkortostan, Russian Federation 450075, tel. +7 (347) 224-68-03, e-mail: nigmatullinr@mail.ru

The publication reflects the preliminary results of an experimental study of the mechanisms of regeneration of the parietal bones after transplantation of cartilage and elastin biomaterials. The study was conducted on Wistar rats (n = 12): in the first experimental group the critical defect of the parietal bones (5×5 mm) was performed by elastin biomaterial (patent No. 2440148), in the second experimental group — by cartilage biomaterial, in the control group the defect stayed intact. The material was taken for subsequent microscopic examination on the 30th day. It was established that in both experimental groups the experimental defect is almost completely represented by the attached biomaterials after a month. Both types of biomaterials induce angiogenesis, proliferation of fibrous connective tissue, and also stimulate the formation of osteogenic foci in the zone of contact with the bone bed, optimizing the processes of regeneration of the cranial vault bones.

Key words: defect of parietal bones, elastic biomaterial, cartilagineus biomaterial, osteogenesis.

REFERENCES

1. Shevtsov V.I., D’yachkov A.N., Chirkova A.M., Ir’yanov Yu.M. Regeneratsiya kostey cherepa pri chreskostnom osteosinteze [Regeneration of the bones of the skull during transosseous osteosynthesis]. Moscow: “Meditsina”, 2005. 167 p.
2. Omel’yanenko N.P., Mishina E.S., Poletaeva M.P., Volkov A.V., Kovalev A.V. Strukturnaya dinamika voloknistoy osnovy temennykh kostey krysy v ontogeneze [Structural dynamics of the fibrous base of rat parietal bones in ontogenesis]. Materialy Vserossiyskoy nauchnoy konferentsii “Sovremennye problemy gistologii i patologii skeletnykh tkaney”. Ryazan, 2018. Pp. 25–26.
3. Eolchiyan S.A. Plastics of complex defects of the skull with implants made of titanium and polyetheretherketon (PEEK) manufactured using CAD. Voprosy neyrokhirurgii imeni N.N. Burdenko, 2014, vol. 78, no. 4, pp. 3–13 (in Russ.).
4. Harris D.A., Abigail J. Fong, Buchanan E.P., Monson L., Khechoyan D., Lam S. History of synthetic materials in alloplastic cranioplasty. Neurosurgical Focus, 2014, vol. 36: issue 4, pp. 1–5.
5. Lee S.-Ch., Wua Ch.-Ts., Lee Sh.-Ts., Chen P.-J. Cranioplasty using polymethyl methacrylate prostheses. Journal of Clinical Neuroscience, 2009, vol. 16, pp. 56–63.
6. D’yachkov A.N., Mukhtyaev S.V., Prudnikova O.G., Mikhaylova E.A. Application of the method G.A. Ilizarov in craniology. Geniy Ortopedii, 2011, no. 2, pp. 49–53 (in Russ.).
7. Greene A.K., Mulliken J.B., Proctor M.R., Rogers G.F. Pediatric cranioplasty using particulate calvarial bone graft. Plastic and Reconstructive Surgery, 2008, vol. 122, no. 2, pp. 563–571.
8. Yasonov S.A., Lopatin A.V., Vasil’ev I.G. Elimination of extensive defects of the skull in children with the help of cranial autografts. Annaly plasticheskoy, rekonstruktivnoy i esteticheskoy khirurgii, 2011, no. 2, pp. 19–30 (in Russ.).
9. Lekishvili M.V., Sklyanchuk E.D., Akatov V.S., Ochkurenko A.A., Gur’ev V.V. et al. Osteoplastic osteoinductive materials in traumatology and orthopedics. Zhurnal klinicheskoy i eksperimental’noy ortopedii imeni G.A. Ilizarova, 2015, no. 4, pp. 61–67 (in Russ.).
10. Akhmedov Sh.M., Musina L.A., Kocharyan E.Z., Ryabov A.Yu., Lekishvili M.V. Experimental morphological study of osteoplastic materials for the surgical treatment of ENT pathology. Geny & Kletki, 2015, vol. X, no. 1, pp. 41–47 (in Russ.).
11. Lim S.C., Lee M.J., Yeo H.H. Effects of various implant materials on regeneration of calvarial defects in rats. Pathology International, 2000, vol. 50, no. 8, pp. 594–602.
12. Shcherbakov D.A. Principles of restoration of the walls of the paranasal sinuses by allografts. Vestnik Orenburgskogo gosudarstvennogo universiteta, 2015, no. 1 (176), pp. 150–155 (in Russ.).
13. Muldashev E.R., Nigmatullin R.T., Galimova V.U. et al. Ksenogennyy biomaterial dlya regenerativnoy khirurgii: patent no. 2440148, prioritet 21.12.2009, opublik. 20.01.2012, byul. no. 2 [Xenogenic biomaterial for regenerative surgery: patent No. 2440148. Priority 12/21/2009, published. 01/20/2012, bul. No. 2].
14. Nigmatullin R.T., Kutushev R.Z. The use of elastin biomaterial in reconstructive surgery of the orbital walls. Prakticheskaya meditsina, 2016, no. 6 (98), pp. 119–121 (in Russ.).
15. Nigmatullin R.T., Kutushev R.Z., Motygullin B.R. Elastin biomaterial as an osteogenesis inducer. Prakticheskaya meditsina, 2017, no. 9 (110), pp. 149–151 (in Russ.).
16. Vajgel A., Mardas N., Farias B.C., Petrie A., Cimões R., Donos N. A systematic review on the critical size defect model. Clinical Oral Implants Research, 2014, vol. 25 (8), pp. 879–893.
17. Nigmatullin R.T., Gizatullina E.R., Motygullin B.R. The role of monocyte-macrophage system in the dynamics of replacement regeneration in the transplantation of elastin biomaterial. Rossiyskiy immunologicheskiy zhurnal, 2017, vol. 11 (20), no. 2, pp. 179–182 (in Russ.).
18. Ghiacci G., Graiani G., Ravanetti Fr., Lumetti S., Manfredi E. et al. «Over-inlay» block graft and differential morphometry: a novel block graft model to study bone regeneration and host-to-graft interfaces in rats. Journal of Periodontal and Implant Science, 2016, vol. 46 (4), pp. 220–233.
19. Bychkov A.I., Doliner M.E., Sitdikova A.I., Volkov A.V., Rachinskaya O.A. The study of osteoinductive activity of recombinant bone morphogenetic protein (rhBMP-2) in the composition of osteoplastic material based on demineralized matrix in the experiment. Stomatologiya dlya vsekh, 2013, no. 3, pp. 16–20 (in Russ.).
20. Anabami N., Mithieux S.M., Camci-Unal G., Dokmeci M.R., Weiss A.S., Khademhosseini A. Elastomeric recombinant proteinbased biomaterials. Biochemical Engineering Journal, 2013, vol. 77, pp. 110–118.