E.V. KHAZOVA, O.V. BULASHOVA

Kazan State Medical University, Kazan

 Contact details:

Khazova E.V. — PhD (medicine), Associate Professor of the Department of Department of Propedeutics of Internal Diseases named after Prof. S.S. Zimnitsky

Address: 49 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7-905-313-97-10, e-mail: hazova_elena@mail.ru

The article provides an overview of the studies of sympathoadrenal system activity in the patients of cardiovascular continuum. The analyzed publications show an excess of β-APM in patients with arterial hypertension, ischemic heart disease, rhythm disturbances, and heart failure in comparison with healthy individuals. The features of the course and development of cardiovascular system complications in patients with myocardial infarction at various β-APM levels are shown. The dynamics of β-APM level was demonstrated in patients with resistant hypertension after renal denervation and patients with myocardial infarction during a year. The level of β-ARM ≥ 49,53 conv. units is revealed at which the risk of CHF progression increases in patients with MI (OR 5,48; 95% CI 1,28–23,37; p = 0,024). Correlations of β-APM value with SHORC, heart rate, data of a 6-minute walking test in CHF patients are presented. The data of the β-APM and polymorphism of the ADRB1 and ADRB2 genes studies are presented. The prognostic significance of determining the adrenergic reactivity by the value of β-adrenergic reception of cell membranes for determining the individual sensitivity of the organism to β-adrenergic blockers is shown. The associations obtained suggest a genetic predisposition to SAS hyperactivation and β-APM use for personalized selection of the β-adrenergic blocker dosage.

Key words: adrenergic reactivity of the body, heart failure, β-APM, sympatho-adrenal system.

REFERENCES

1. Brahmbhatt D.H., Cowie M.R. Heart failure: classification and pathophysiology. Medicine, 2018, vol. 46 (10), rr. 587–593.
2. Antoine S., Vaidya G., Imam H. et al. Pathophysiologic Mechanisms in Heart Failure: Role of the Sympathetic Nervous System. The American Journal of the Medical Sciences, 2017, vol. 353 (1), rr. 27–30.
3. Rebrova T.Yu., Muslimova E.F., Aleksandrenko V.A. et al. Dynamics of adrenergic reactivity after myocardial infarction: one-year follow-up. Terapevticheskiy arkhiv, 2021, vol. 93 (1), pp. 44–48 (in Russ.).
4. Khazova E.V., Bulashova O.V., Oslopov V.N. et al. The value of determining the body’s adrenergic reactivity and polymorphisms of the β-adrenergic receptor gene in the development of myocardial remodeling in patients with chronic heart failure. Serdechnaya nedostatochnost‘, 2013, vol. 1 (75), pp. 34–39 (in Russ.).
5. Bazyan A.S. Fiziologicheskaya rol’ autoadrenoretseptorov [Physiological role of autoadrenoreceptors]. Moscow: Nauka, 1991. 159 p.
6. Krasnikova T.L. Beta-2-adrenoretseptornaya sistema limfotsitov cheloveka pri nekotorykh serdechno-sosudistykh zabolevaniyakh i deystvii lekarstvennykh preparatov: avtoref. dis. … dokt. biol. nauk [Beta-2-adrenergic receptor system of human lymphocytes in some cardiovascular diseases and the action of drugs. Synopsis of dis. Dr biol. sciences]. Moscow, 1993. 59 p.
7. Bristow M.R., Ginsburg R., Minobe W. Decreased catecholamine sensivity and beta-adrenergic receptor density in failure human hearts. New Engl. J. Med, 1982, vol. 307 (2), pp. 205–211.
8. Stryuk R.I., Dlusskaya I.G. Adrenoreaktivnost’ i serdechno-sosudistaya sistema [Adrenoreactivity and cardiovascular system]. Moscow: Meditsina, 2003. 160 p.
9. Bunova S.S. Gipertonicheskaya bolezn’: narushenie psikhoneyrogumoral’nykh vzaimootnosheniy i sposoby ikh korrektsii: avtoref. dis. … dokt. biol. nauk [Essential hypertension: violation of psychoneurohumoral relationships and methods of their correction. Synopsis of dis. Dr biol. sciences]. Omsk, 2009. 46 p.
10. Vorob’eva O.V., Dmitriev A.O. Prediction of the course and outcome of atherothrombotic stroke based on the assessment of the activity of erythrocyte adrenergic receptors and the clinical picture. Zhurnal nevrologii i psikhiatriya, 2014, vol. 8 (2), pp. 52–56 (in Russ.).
11. Zyubanova I.V., Fal’kovskaya A.Yu., Mordovin V.F. et al. Peculiarities of changes in beta-adrenergic reactivity of erythrocyte membranes in patients with resistant arterial hypertension after renal denervation, relationship with antihypertensive and cardioprotective efficacy of intervention. Kardiologiya, 2021, vol. 61 (8), pp. 32–39 (in Russ.).
12. Nechaeva G.I. Adrenoreactivity in patients with arrhythmic syndrome associated with connective tissue dysplasia while taking magnesium orotate. Kardiologiya, 2011, no. 3, pp. 54–57 (in Russ.).
13. Borisova E.V., Afanas’ev S.A., Rebrova T.Yu. et al. Changes in adrenoreactivity in patients with paroxysmal atrial fibrillation while taking sotalol, depending on the tone of the autonomic nervous system. Terapevticheskiy arkhiv, 2016, vol. 88 (1), pp. 35–39 (in Russ.).
14. Afanas’ev S.A., Rebrova T.Yu., Muslimova E.F., Borisova E.V. Association of polymorphic variants of the ADRB1 gene with contractile dysfunction of the myocardium and adrenoreactivity of erythrocytes in patients with arrhythmias. Rossiyskiy kardiologicheskiy zhurnal, 2019, vol. 24 (7), pp. 47–52 (in Russ.).
15. Bulashova O.V., Malkova M.I. Adrenoreactivity as a prognostic criterion of perioperative cardiac complications in extracardiac surgery. Kazanskiy meditsinskiy zhurnal, 2012, vol. 93, no. 2, pp. 177–181 (in Russ.).
16. Aymagambetova A.O., Karazhanova L.K., Kotlyar A. et al. Risk stratification of adverse cardiovascular events in acute myocardial infarction with ST segment elevation. Nauka i zdravookhranenie, 2016, no. 5, pp. 131–141 (in Russ.).
17. Vorob’eva D.A., Rebrova T.Yu., Afanas’ev S.A., Ryabov V.V. Comparative analysis of erythrocyte adrenoreactivity in patients with myocardial infarction depending on the severity of coronary obstruction. Rossiyskiy kardiologicheskiy zhurnal, 2020, vol. 25 (5), p. 3735 (in Russ.).
18. Malkova M.I., Bulashova O.V., Khazova E.V. Determination of the body’s adrenergic reactivity by adrenergic reception of the cell membrane in cardiovascular pathology. Prakticheskaya meditsina. Kardiologiya, 2013, vol. 3 (13), pp. 20–23 (in Russ.).
19. Garganeeva A.A., Aleksandrenko V.A., Kuzheleva E.A. et al. Vzaimosvyaz’ beta-adrenoreaktivnosti eritrotsitov i osobennostey techeniya ostrogo infarkta miokarda. Kompleksnye problemy serdechno-sosudistykh zabolevaniy [The relationship between beta-adrenoreactivity of erythrocytes and the characteristics of the course of acute myocardial infarction. Complex problems of cardiovascular diseases], available at: https://www.nii-kpssz.com/jour/article/view/909/569
20. Garganeeva A.A., Aleksandrenko V.A., Kuzheleva E.A. et al. Association of the beta-adrenoreactivity index of erythrocyte membranes in myocardial infarction with genetic characteristics of the beta-adrenergic receptor apparatus. Yuzhno-Rossiyskiy zhurnal terapevticheskoy praktiki, 2021, vol. 2 (1), pp. 32–39 (in Russ.).
21. Khazova E.V., Bulashova O.V., Oslopov V.N., Kravtsova O.A. he value of determining the body’s adrenergic reactivity and polymorphisms of the B2-adrenergic receptor gene in the development of myocardial remodeling in patients with chronic heart failure. Zhurnal serdechnaya nedostatochnost‘, 2013, vol. 14, no. 1, pp. 34–39 (in Russ.).
22. Bulashova O.V., Oslopov V.N., Khazova E.V. Adrenoreactivity in patients with chronic heart failure. Prakticheskaya meditsina, 2011, vol. 4 (52), pp. 72–74.
23. Gazizyanova V.M., Bulashova O.V., Nasybullina A.A. et al. Cardiopulmonary syndrome and adrenergic reactivity of the body. Kazanskiy meditsinskiy zhurnal, 2016, no. 97 (6), pp. 864–869 (in Russ.).
24. Bunova S.S., Ostapenko V.A., Nikolaev N.A. Arterial hypertension and adrenoreactivity: features in obese patients. Byull. SO RAMN, 2008, vol. 1 (129), pp. 77–81 (in Russ.).
25. Aleksandrenko V.A., Rebrova T.Yu., Afanas’ev S.A., Garganeeva A.A. The relationship of adrenergic reactivity with the stage of chronic heart failure in patients with myocardial infarction. Sibirskiy meditsinskiy zhurnal, 2019, vol. 34 (2), pp.79–83 (in Russ.).
26. Garganeeva A.A., Aleksandrenko V.A., Kuzheleva E.A., Rebrova T.Yu. Beta-adrenoreactivity of erythrocytes and the progression of chronic heart failure in patients with myocardial infarction. Rossiyskiy kardiologicheskiy zhurnal, 2020, vol. 25 (1), p. 3407.
27. Linnik S.A., Naurbieva E.N., Ponomareva E.P. Effect of angiotensin-converting enzyme inhibitor perindopril on heart rate variability and adrenergic reactivity in patients with coronary heart disease combined with duodenal ulcer. Kardiologiya, 2007, no. 4, pp. 41–44 (in Russ.).
28. Korobova A.A. Dynamics of cognitive and emotional disorders in the treatment of initial discirculatory encephalopathy against the background of arterial hypertension with beta-blockers depending on adrenoreactivity. Nevrologiya, 2009, vol. 13, no. 1 (46), pp. 107–112 (in Russ.).
29. Krasyukova V.A. Kliniko-patogeneticheskie osobennosti sochetaniya arterial’noy gipertenzii i sakharnogo diabeta 2 tipa i farmakologicheskaya korrektsiya endotelial’noy disfunktsii: avtoref. dis. … kand. med. nauk [Clinical and pathogenetic features of the combination of arterial hypertension and type 2 diabetes mellitus and pharmacological correction of endothelial dysfunction. Synopsis of dis. PhD med. sciences]. Voronezh, 2010. 22 p.
30. Borisova E.V., Afanas’ev S.A., Rebrova T.Yu. et al. Evaluation of beta-adrenoreactivity in sympathicotonic and vagotonic disorders in patients with paroxysmal atrial fibrillation while taking sotalol. Sibirskiy meditsinskiy zhurnal, 2015, vol. 30, no. 1, pp. 71–75 (in Russ.).