V.G. LIKHVANTSEVA¹_, I.V. KOVELENOVA⁴, M.V. SOLOMATINA², BEN REDJEB AMIN¹, A.G. GABIBOV³, A.A. BELOGUROV³

¹Institute of Advanced Training of the Federal Medical-Biological Agency of Russia, 91 Volokolamskoe Road, Moscow, Russian Federation, 125371

²Clinical Hospital named after N.A. Semashko, 3 Semashko St., Ryazan, Russian Federation, 390005;

³Institute of Bioorganic Chemistry named after academicians M.M. Shemyakin and Yu.A. Ovchinnikov of the Russian Academy of Sciences, 16/10 Miklukho-Maklai St., Moscow, Russian Federation, 117997

⁴Ulyanovsk Regional Clinical Hospital, 7 III Internatsyonala St., Ulyanovsk, Russian Federation, 432017

Likhvantseva V.G. ― D. Med. Sc., Professor of the Department of Eye Diseases of the Federal Medical-Biological Agency, tel. +7-916-659-41-56, e-mail: likhvantseva-4@yandex.ru

Kovelenova I.V. ― Cand. Med. Sc., Head of the Department of Eye Microsurgery, tel. +7-927-634-30-09, e-mail: kiv-06@list.ru

Solomatina M.V. ― ophthalmologist of the 2^nd Ophthalmology Department, tel. +7-910-568-83-79, e-mail: maria.vikto@gmail.com

Ben Redjeb Amin ― postgraduate student of the Department of Eye Diseases, tel. +7-977-291-99-86, e-mail: coachamine@hotmail.ru

Gabibov A.G. ― D. Chem. Sc., Professor, corresponding member of the RAS, Head of the Biocatalysis Laboratory, tel. (495) 727-38-60, e-mail: gabibov@mx.ibch.ru

Belogurov A.A. ― Cand. Chem. Sc., Senior Researcher of the Biocatalysis Laboratory, tel. (495) 727-38-60, e-mail: belogurov@mx.ibch.ru

The authors have conducted serological studies with the quantitative assessment of 9 anti-SP antibodies participating in anti-apoptotic protection, control of immunomolecular homeostasis and tissue homeostasis in 82 patients with primary open-angle glaucoma. It was established that glaucoma develops against the background of simultaneous deficiency of anti-SP antibodies that control integrity of cellular cytoskeleton: anti-actin, anti-fodrin, and anti-thymosin ß4 antibodies. Antibodies deficiency grew. Simultaneously increased immunomolecular signs of apoptotic cellular death in the form of rising antibodies consumption to specific antigens ― GADPH, rhodopsin, ENO, NSE-1 ― have increased. Manifestation of the disease was accompanied by release of anti-MBP catalytic antibodies participating in destruction of axons and stimulation of production of anti-crystallin antibodies responsible for reparative processes and antioxidative protection in the cell. Obtained data unveil the opportunities of molecular diagnostics and evaluation of glaucoma efficiency.

Key words: immunomolecular markers, primary open-angle glaucoma, blood serum, diagnostics.