R.Z. SHAMMASOV, I.V. OSIPOVA, E.I. NIZAMUTDINOVA, E.N. GRISHINA, L.R. KARIMOVA

Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, 140 Orenburgsky Trakt, Kazan, Russian Federation, 420138

 Shammasov R.Z. — Head of Onco-Hematology Department, tel. (843) 237-30-07, e-mail: rafael.shammasov@tatar.ru

Osipova I.V. — doctor-hematologist of Onco-Hematology Department, tel. (843) 237-30-07, e-mail: ivos29@mail.ru

Nizamutdinova E.I. — doctor-hematologist of Onco-Hematology Department, tel. (843) 237-30-07, e-mail: helennizam@hotmail.com

Grishina E.N. — doctor-hematologist of Onco-Hematology Department, tel. (843) 237-30-07, e-mail: barieved@mail.ru

Karimova L.R. — doctor-hematologist of Onco-Hematology Department, tel. (843) 237-30-07, e-mail: drkb.onco@mail.ru

Development of the second tumor is one of the severe remote complications of chemoradiation therapy of oncological diseases. It is observed in 2-5% of all treated patients. The article analyzes 8 cases of second tumors in children and adolescents aged 2 to 17. The structure of the first tumors included 77.8% cases of solid tumors and 22.2% of hemoblastoses. The patients were treated with radiotherapy as well as antitumoral drugs with mutagenic properties. The second tumor was diagnosed 6 to 96 months after the treatment completion. The second tumor was an acute myeloblastic leukemia in 50% cases, 2 cases of soft tissue sarcoma, 1 case of goitrous tumor and 1 case of brain tumor. The efficiency of the second tumor treatment depends on the time of its appearance, histological variant and localization, as well as the toxicity of the previous therapy. Out of 8 patients, 2 are alive (25%). The experience of successful treatment of the second tumor is presented as a clinical case.

Key words: children, oncological diseases, radiation therapy, chemotherapy, second tumors. 

REFERENCES

1. Detskaya onkologiya. Natsional’noe rukovodstvo, pod red. M.D. Alieva, V.G. Polyakova, G.L. Mentkevicha, S.A. Mayakovoy [Children’s Oncology. National leadership. Ed. by M.D. Aliyev, V.G. Polyakov, G.L. Mentkevich, S.A. Mayakova]. Moscow: Izdatel’skaya gruppa RONTs, 2012. Pp. 640-649.
2. Zaeva G.E., Valiev T.T., Gavrilenko T.F., Moseenko E.I. et al. Long-term effects of cancer treatment in children: 35-year experience of clinical observations. Sovremennaya onkologiya, 2016,  vol. 18, no. 1, pp. 55-60 (in Russ.).
3. Shcherbenko O.I. The second tumor in patients undergoing anticancer therapy in childhood. Statistics, etiology, ways of preventing. Vestnik RNTsRR MZ RF, no.13, 2013 (in Russ).
4. Friedman D.L., Whitton J., Leisenring W. et al. Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J. Natl Cancer Inst, 2010, vol. 102, no. 14, pp.1083-1095.
5. Olsen J.H., Möller T., Anderson H.et al. Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. J. Nat. Cancer Inst, 2009, vol. 101, no. 11, pp. 806-813.
6. Gematologiya/onkologiya detskogo vozrasta, pod red. A.G. Rumyantseva, E.V. Samochatovoy [Hematology/Oncology childhood. Ed. by A.G. Rumyantsev, E.V. Samochatova]. Moscow: Medpraktika-M, 2004. 792 p.
7. Rukovodstvo po khimioterapii opukholevykh zabolevaniy, pod red. N.I. Perevodchikovoy, V.A. Gorbunovoy [Guide chemotherapy of neoplastic diseases. Ed. by N.I. Perevodchikova, V.A. Gorbunova]. Moscow: Prakticheskaya meditsina, 2015.
8. Armstrong G.T., Stovall M., Robison L.L. Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study. Res. Radiat, 2010, vol. 174, no. 6, pp. 840-850.
9. Borisova M.V., Il’enkova N.A., Kadricheva T.G. The case of a secondary tumor in a child with Hodgkin’s lymphoma. Detskaya onkologiya, 2013, no. 1-3, pp. 55-58 (in Russ.).
10. Gerasimova O., Shapochnik A.P., Klimushkin A.V., Sidorenko L.V. Second tumors in patients cured of malignant neoplasms in childhood. Materialy Kongressa SIOP Asia-2016. Abstract No, p. 399.