D.I. SADYKOVA¹, E.V. SERGEYEVA¹, G.N. AFLYATUMOVA²

¹Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012

²Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, 140 Orenburgskiy trakt, Kazan, Russian Federation, 420063

Sadykova D.I. — D. Med. Sc., Professor of the Department of Hospital Pediatrics, tel. (843) 237-30-37, e-mail: sadykovadi@mail.ru

Sergeyeva E.V. — postgraduate student of the Department of Hospital Pediatrics, tel. +7-919-620-02-62, e-mail: evs131@mail.ru

Aflyatumova G.N. — cardiologist, tel. +7-987-296-75-36, e-mail: aflyatumovagulfia@mail.ru

The article presents a literature review of the modern endotheliology. The role of the endothelium in the regulation of vascular tone is stated; the mechanisms of endothelial dysfunction are shown; the NO-dependent mechanisms of hypertension are discussed; the value of free-radical oxidation and antioxidant defense system is described in the development of endothelial dysfunction and hypertensionin children and adolescents.

Key words: arterial hypertension, children, adolescents, endothelial dysfunction, nitric oxide, endothelin.

 

 

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