E.R. MEKHTIYEVA, A.G. YASHCHUK, R.M. ZAYNULLINA, I.I. MUSIN

Bashkir State Medical University, 3 Lenin Str., 450008 Ufa, Russian Federation

Mekhtiyeva E.R. — clinical intern of the Department of Obstetrics and Gynecology No. 2, tel. +7-919-606-98-85, e-mail: elvirochka-azn@mail.ru

Yashchuk A.G. — D. Med. Sc., Professor, Head of the Department of Obstetrics and Gynecology No. 2, tel. 8(347)264-96-50

Zaynullina R.M. — Cand. Med. Sc., Associate Professor of the Department of Obstetrics and Gynecology No. 2, tel. 8 (347) 264-96-50, e-mail: raisa.bsmu@gmail.com

Musin I.I. — Cand. Med. Sc., Assistant Lecturer of the Department of Obstetrics and Gynecology No. 2, tel. +7-917-467-10-64, e-mail: ilnur-musin@yandex.ru

 The article describes the results of molecular genetic analysis of genes collagen type 1 (Col1A1), vitamin D receptor (VDR) and collagen type 3 (Сol3A1) in women with different degree of ptosis and prolapse of internal genital organs. A comparative analysis of genes with a control group of healthy women was carried out. In the study it was revealed that the SpI polymorphism of the collagen type 1 (Col1A1), gene Fok1 polymorphism of vitamin D receptor (VDR), VNTR and Alu gene polymorphism of collagen type 3 (Сol3A1) could be the genes involved in the pathogenesis of insolvency of the pelvic floor and markers for increased risk of this disease.

Key words: genital prolapse, vitamin D receptors, genes of collagen type 1, genes of collagen type 3.

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