E.V. AGAFONOVA^1,3, T.G. МALANICHEVA ^1,2, N.V. ZIATDINOVA¹

¹Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

²Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, 140 Orenburgskiy Trakt, Kazan, Russian Federation, 420138

³ Kazan Scientific and Research Institute of Epidemiology and Microbiology of Rospotrebnadzor, 67 B. Krasnaya Str., Kazan, Russian Federation, 420057

Agafonova E.V. ― Cand. Med. Sc., assistant of the Department of Propaedeutics of Children’s Diseases with the course of the departmental pediatrics and the course of childhood diseases of the department of general medicine, Head of a clinical and diagnostic laboratory, tel. +7-917-876-16-44, e-mail: Agafono@mail.ru.

Malanicheva T.G. ― D. Med. Sc., Professor of the Department of Propaedeutics of Children’s Diseases with the course of the departmental pediatrics and the course of childhood diseases of the department of general medicine, Doctor immunologist and allergologist of the consultative polyclinic of the CRCH, tel. (843) 268-58-21, e-mail: tgmal@mail.ru.

Ziatdinova N.V. ― Cand. Med. Sc., Associate Professor of the Department of Propaedeutics of Children’s Diseases with the course of the departmental pediatrics and the course of childhood diseases of the department of general medicine, tel. (843) 268-58-21, e-mail: ziatdin@mail.ru

The population profile and the receptor apparatus of peripheral monocytes in children with secondary chronic pyelonephritis have come under review. The subpopulations CD14 ++ CD16-, CD14 + CD16 +, CD14 + HLADR +, CD14 + 11b + and phagocytic activity of monocytes are studied. Changing subpopulation profile of monocytes is associated with a decrease of the subpopulation of CD14 + CD16 + («classic») that is determined by the intense transmigration into a hotbed of chronic inflammation and an increase of the subpopulation of CD14 + CD16 + («pro-inflammatory»). The question of the suppressor function of CD14 ++ CD16 is being discussed. Change of a subpopulation profile defines the disorder of the cell’s functional characteristics ― antigen-presenting and phagocytic.

Кеу words: chronic pyelonephritis, children, monocytes, subpopulation.

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