M.E. ZHELEZOVA¹, L.I. MALTSEVA¹, T.P. ZEPHIROVA¹, N.Yu. CHISTIAKOVA², S.S. KANYUKOV³

¹Kazan State Medical Academy ― Branch Campus of the FSBEI FPE RMACPE MOH Russia, 36 Butlerov Str., Kazan, Russian Federation, 420012

²Medical-Sanitary Department of Kazan Federal University, 51 Bolshaya Krasnaya Str., Kazan, Russia, 420012

³Republican Clinical Hospital, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064

 Zhelezova M.E. ― PhD (medicine), Associate Professor of the Department of Obstetrics and Gynecology №1, e-mail: gelezovam@gmail.com, ORCID ID: 0000-0002-2006-0110

Maltseva L.I. ― D. Sc. (medicine), Professor, Head of the Department of Obstetrics and Gynecology №1, e-mail: laramalc@mail.ru

Zephirova T.P. ― D. Sc. (medicine), Professor of the Department of Obstetrics and Gynecology №1, e-mail: tzerirova@gmail.com

Chistyakova N.Yu. ― PhD (medicine), Head of the Maternity Department, e-mail: ninadoc@rambler.ru, ORCID ID: 0000-0002-2907-2409

Kanyukov S.S. ― obstetrician-gynecologist, e-mail: ckanukow@gmail.com, ORCID ID: 0000-0002-0879-8569

 Objective ― to systematically analyze the foreign and Russian research on the role of oral and gut microbiota in the development of obstetric complications.

Material and methods. The review includes data from foreign and Russian articles found in Pubmed database published over the past 8 years, on changes in oral-intestinal microbiome during pregnancy. The research results are described, which analyze various mechanisms of influence of microbiome of these locuses on the development of obstetric and perinatal complications.

Results. Throughout a human life, microbiome performs vital functions such as barrier function, metabolic reactions, trophic effects and maturation of the host’s innate and adaptive immune response. It is shown that non-gravidar and gravidar microbiome of the oral cavity and intestines has significant differences. The microflora during pregnancy is more stable and less diverse, which seems to be a necessary condition for maintaining gravidar homeostasis. The role of oral-intestinal microbiota in the development of premature birth, cardiometabolic complications of pregnancy, pre-eclampsia is proved. The research results show that some bacteria that are commensals in their normal habitats, after migrating into the placenta become absolute pathogens and cause various complications of pregnancy.

Conclusion. The search for methods of correction of microbiotic dysbiotic disorders during pregnancy will improve maternal and perinatal outcomes and, at the moment, appears to be one of the current trends in obstetrics.

Key words: pregnancy, oral microbiome, gut microbiome, obstetric complications.

(For citation: Zhelezova M.E., Maltseva L.I., Zephirova T.P., Chistyakova N.Yu., Kanyukov S.S. Role of oral-intestinal microbiome in the development of obstetric complications. Practical Medicine. 2018)

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