Yu.K. ALEKSANDROV, A.M. SIROTKINA, A.L. KHOKHLOV, S.N. PAMPUTIS, A.D. DYAKIV

Yaroslavl State Medical University, Yaroslavl

 Contact details:

Aleksandrov Yu.K. ― MD, Head of the Department of Surgical Diseases

Address: 5 Revolyutsionnaya Str., Yaroslavl, Russian Federation, 150000, tel. (4852) 30-56-41, e-mail: yka2000@mail.ru

 Objective. The work is devoted to rehabilitation, evaluation of postoperative management and prevention of rehabilitation risks in patients after thyroid surgery.

Material and methods. Based on the study of rehabilitation period in 208 patients operated for various thyroid diseases, the evaluation of replacement and suppressive therapy with thyroid hormones is given.

Results. After organ-preserving operations on the thyroid gland, changes in the internal organs are minimal. Most often they do not need correction. After radical and some organ-preserving operations, there is a need for therapy with thyroid hormones due to the development of hypothyroidism. The study of the features of the cardiovascular system reaction and the changes in psychological status of patients during L-thyroxine therapy showed that the side effects, negative reactions and complications do not have a clear direct correlation with the dose of the prescribed drug. Also, they are not associated with morphological changes that were the basis for thyroid surgery. Selection of the L-thyroxine dose in each case is individual and requires taking into account the age of patients, the presence of comorbid pathology and its severity, as well tolerability. The individual response is determined by many factors, including genetic polymorphism of patients, which affects the pharmacokinetics of the drug, its metabolism and body reactions.

Conclusion. Today, pharmacogenetic testing is an important and necessary component of the patients examination before thyroid surgery and in the planning of L- thyroxine therapy.

Key words: thyroid gland, postoperative period, rehabilitation, pharmacogenetic testing.

(For citation: Aleksandrov Yu.K., Sirotkina A.M., Hohlov A.L., Pamputis S.N., Dyakiv A.D. Risk reduction and rehabilitation after operations on the thyroid gland. Practical medicine. 2019. Vol. 17, № 4, P. 133-136)

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