S. MAZURENKO^1,2, S.K. MALYUTINA¹, L.V. SHCHERBAKOVA¹, Yu.I. RAGINO¹, O.D. RYMAR¹

 ¹ Research Institute of Therapy and Preventive Medicine — Branch of the Federal research Center «Institute of Cytology and Genetics», Siberian Branch of Russian Academy of Sciences, 175/1 Boris Bogatkov Str., Novosibirsk, Russian Federation, 630089

² Novosibirsk Research Institute of Traumatology and Orthopedics, n.a. Ya.L. Tsivyan, 17 Frunze, Novosibirsk, Russian Federation, 630091

 Mazurenko E.S. — post-graduate student, endocrinologist, e-mail: poltorackayaes@gmail.com; ORCID: 0000-0003-3351-1993

Malyutina S.K. — D. Sc. (medicine), Professor, Head of the Laboratory of Etiopathogenesis and Clinic of Internal Diseases, tel. (383) 267-97-55, e-mail: smalyutina@hotmail.com, ORCID: 0000-0001-6539-0466

Shcherbakova L.V. — Senior Researcher, tel. (383) 267-97-55, e-mail: smalyutina@hotmail.com, ORCID: 0000-0001-9270-9188

Ragino Yu.I — D. Sc. (medicine), correspondent member of the Russian Academy of Sciences, Head of the Laboratory of Clinical Biochemical and Hormone Research of Therapeutic Diseases, tel. (383) 267-97-55, e-mail: ragino@mail.ru, ORCID: 0000-0002-4936-8362

Rymar O.D. — D. Sc. (medicine), Leading Researcher, Head of the Laboratory of Clinical-population and Preventive Research of Therapeutic and Endocrinal Diseases, tel. 267-97-55, e-mail: orymar23@gmail.com, ORCID: 0000-0003-4095-0169

To identify the most significant risk factors for distal forearm fractures (DFF) in women older than 50 years.

Material and methods. A cross-sectional study was conducted in 2015–2017 as part of the international project HAPIEE. The analysis included a sample of postmenopausal women 58–84 years old (n=2315). All project participants underwent examination that included: collecting information about fractures during lifetime and in the recent 13 years, the presence of risk factors for chronic noncommunicable diseases (NCD), the duration of menopause, the consumption of coffee and calcium from food, anthropometric measurements (height, weight, waist circumference (WC), with the calculation of body mass index (BMI)), assessment of physical functioning, study of biochemical parameters of blood serum (fasting plasma glucose, lipid profile). Statistical data processing was performed using the SPSS software (v.13.0).

Results. The prevalence of post-menopausal fractures in postmenopausal women is high (during lifetime – 16.9%, over the recent 13 years – 10.6%). In the group of women with DFF, physical activity was higher (p = 0.045), and the indicators of BMI, WC, TG, fasting blood glucose, the amount of Ca consumed were lower than in women without fractures (p = 0.001, p = 0.001, p = 0.037, p = 0.022, p = 0.010, respectively). The chance of wrist fractures in women increases with smoking, fractures in history, and daily Ca consumption less than 1000 mg.

The conclusion. The regenerative abilities of the bone tissue in women are reduced in postmenopausal period, which is the reason for such a high incidence of osteoporotic fractures. The greatest contribution to predicting the risk of fractures is made by reduced calcium intake, smoking, and a history of fractures. The data obtained indicate the need for preventive measures against repetitive osteoporotic fractures.

Key words: osteoporosis, low-energy fractures, risk factors for chronic low incidence disorders.

(For citation: Mazurenko E.S., Malyutina S.K., Shcherbakova L.V., Ragino Yu.I., Rymar O.D. Risk factors of osteoporotic distal forearm fractures in postmenopausal women in Novosibirsk. Practical Medicine. 2018)

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