A.V. NIKOLAEVA, L.T. PIMENOV, M.V. DUDAREV, A.V. MELNIKOV

Izhevsk State Medical Academy, 281 Kommunarov Str., Izhevsk, Russian Federation, 426034

Nikolaeva A.V. ― Cand. Med. Sc., Associate Professor of the Department of Polyclinic Therapy with the courses in Clinical Pharmacology and Preventive Medicine, tel. +7-912-464-18-50, e-mail: allavn@inbox.ru

Pimenov L.T. ― D. Med. Sc., Professor, Head of the Department of General Practitioner and Internal Diseases with the course in Emergency Medical Aid, tel. +7-912-851-23-30, e-mail: pimenov45@yandex.ru

Dudarev M.V. ― D. Med. Sc., Associate Professor, Head of the Department of Polyclinic Therapy with the courses in Clinical Pharmacology and Preventive Medicine, tel. +7-912-767-28-33, e-mail: flatly@yandex.ru

Melnikov A.V. ― Cand. Med. Sc., Assistant of the Department of Polyclinic Therapy with the courses in Clinical Pharmacology and Preventive Medicine, tel. +7-912-851-44-67, e-mail: forma45@mail.ru

The article presents the results of examination of 187 female patients with primary hypothyroidism depending on the level of thyroid failure. The research included the assessment of clinical, hemodynamic parameters, lipid and hormonal profile, endothelium function and kidney filtration function. It was demonstrated that the examined patients had such risk factors as obesity, arterial hypertension, atherogenic dyslipidemia, endothelium dysfunction, subclinical atherosclerosis, diastolic dysfunction and left ventricle hypertrophy. The disease compensation and long-term levothyroxine therapy did not lead to the significant decrease of risk factor severity.

Key words: primary hypothyroidism, risk factors, dyslipidemia, endothelium dysfunction.

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