A.D. YUDITSKIY¹, M.P. GRIGORIEVA²

 ¹Izhevsk State Medical Academy, Izhevsk

²Republic Children’s Clinical Hospital, Izhevsk

Contact details:

Yuditskiy A.D. — PhD (Medicine), Associate Professor, Department of Pediatrics and Neonatology

Address: 281 Kommunarov St., 426000 Izhevsk, Russian Federation, tel.: +7 (3412) 33-21-46, e-mail: antonyud103ped@mail.ru

The article examines risk factors for the development of retinopathy in premature babies with early-onset intrauterine growth retardation (IUGR).

The purpose was to evaluate the spectrum and clinical significance of antenatal and neonatal risk factors in the development of retinopathy in premature infants born with early-onset intrauterine growth retardation before 32 weeks of gestation.

Material and methods. The retrospective, single-center study included 39 premature infants (gestational age of 24–31 weeks) with diagnosed early-onset intrauterine growth retardation. The observation group consisted of 22 infants with retinopathy of prematurity, while the comparison group consisted of 17 infants without retinopathy of prematurity. Using nonparametric statistical methods (the Mann — Whitney U-test) and relative risk (RR) calculations, we analyzed the influence of obstetric factors, health status in the neonatal period, and treatment technologies on the development of retinopathy of prematurity.

Results. Gestational age at birth less than 28 weeks, birth weight <750 g, congenital pneumonia, invasive mechanical ventilation, and red blood cell transfusions are the main factors determining the stratification of premature infants born with early-onset IUGR into a risk group for developing retinopathy.

Conclusions. The identified risk factors for developing retinopathy in very premature infants born with early-onset IUGR provide the basis for the development and implementation of personalized prevention and correction methods for visual impairment.

Key words: retinopathy of prematurity, intrauterine growth retardation, extremely low birth weight, risk factors.

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