R.I. GABIDULLINA¹, G.A. SMIRNOVA², F.R. NUKHBALA¹, E.V. VALEEVA¹, Yu.I. ORLOVA¹, A.A. SHAKIROV¹, A.F. AKHMETZYANOVA³, G.R. FAKHRUTDINOVA³

¹Kazan State Medical University, Kazan

²City Clinical Hospital №7, Kazan

³Tatarstan Cancer Center, Kazan

  Contact details:

Gabidullina R.I. ― MD, Professor of the Department of Obstetrics and Gynecology named after Prof. V.S. Gruzdev

Address: 49 Butlerov Str., Kazan, Russian Federation, 420012, e-mail: ru.gabidullina@yandex.ru

 Objective ― to determine the frequency of polymorphism of the CYP19A1 gene (rs2414098) in patients with endometrial cancer and healthy women living in the Republic of Tatarstan.

Material and methods. The study included 161 residents of the Republic of Tatarstan. The comparison group consisted of 60 patients with endometrial cancer (endometrial adenocarcinoma), the control group was assembled from 101 women without endometrial pathology. The age of the examined patients ranged from 41 to 91 years. The SNP of the CYP19A1 gene (rs2414098) was determined by real-time polymerase chain reaction. The χ2 test was conducted, and the odds ratio was evaluated.

Results. It was found that the chance of developing endometrial cancer was higher in carriers of the C allele (OR=1.88, 95% CI 1.15 – 3.06, p=0.01) and the C/C genotype (OR=2.11, 95% CI 1.10 – 4.05, p=0.04) of the SNP of the CYP19A1 gene molecule (rs2414098).

Conclusion. Presence of the C allele and the C/C SNP genotype of the CYP19A1 molecule is the risk factor predisposing to the development of endometrial adenocarcinoma in women living in the Republic of Tatarstan.

Key words: endometrial cancer, genetic polymorphism, genetic predisposition.

(For citation: Gabidullina R.I., Smirnova G.A., Nukhbala F.R., Valeeva E.V., Orlova Yu.I., Shakirov A.A., Akhmetzyanova A.F., Fakhrutdinova G.R. Relationship of the single nucleotide polymorphism of the CYP19A1 rs2414098 gene with the risk of endometrioid adenocarcinoma. Practical medicine. 2019. Vol. 17, № 4, P. 68-71)

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