G.R. GAINULLINA¹, E.R. KIRILLOVA^2, 3, A.KH. ODINTSOVA³, D.I. ABDULGANIEVA^2, 3

 ¹City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan

²Kazan State Medical University, Kazan

³Republican Clinical Hospital, Kazan

 Contact details:

Gainullina G.R. — PhD (Medicine), physician

Address: 54 Chuikov St., Kazan, Russian Federation, 420103, tel.: +7 (843) 237-34-83, e-mail: nice.gaynullina@bk.ru

 The purpose — to evaluate the relationship between quality of life parameters and damage to joints and entheses in patients with inflammatory bowel diseases (IBD).

Materials and methods. The study included 95 patients with IBD (ulcerative colitis (UC) and Crohn’s disease (CD)). The quality of life of patients was assessed using the SF-36 questionnaire. Each patient underwent clinical and ultrasound examination of the joints and entheses of the upper and lower extremities. A comparative analysis of the frequency of joint damage and enthesis in patients with UC and CD was carried out. We also assessed the relationship between the number of affected joints and entheses and the quality of life of patients with IBD.

Results. The general parameter of physical well-being was 43.53 (35.67; 51.66), the general parameter of mental well-being was 38.53 (31.13; 48.37). 61 patients with IBD (64%) noted pain in the joints at the time of examination and/or in history. During clinical examination, arthritis was detected in 18 (19%) patients, pain on palpation of entheses was noted in 49 patients (52%). According to ultrasound, synovitis was detected in 41 patients (43%), enthesites were detected in 72 patients (76%). There were no significant differences in the frequency of joint damage and enthesis between patients with different nosologies. An inverse correlation was observed between the number of synovitis with vascularization and scales of physical functioning (SR = -0.26; p = 0.01), vital activity (SR = -0.29; p = 0.005), as well as with the general parameter of physical well-being (SR = -0.23; p = 0.024). The number of enthesitis was inversely correlated with the pain intensity scale (SR = -0.22; p = 0.036).

Conclusion. Joint and enthesis damage in IBD is a common problem associated with the quality of life of patients. Its study is necessary for the timely diagnosis of these lesions and the selection of therapy. Particular attention should be paid to the issue of enthesopathy in IBD, information about which is scarce.

Key words: inflammatory bowel disease, ultrasound, enthesitis, quality of life.

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