Prospects of measuring stress proteins levels as markers of impaired adaptation in newborns
E.V. LOSKUTOVA, Kh.M. VAKHITOV
Kazan State Medical University, Kazan
Contact details:
Loskutova E.V. — Assistant Lecturer of the Department of Hospital Pediatrics
Address: 49 Butlerov St., Russian Federation, Kazan, 420012, tel.: +7-987-421-86-85, e-mail: loskutovakate@mail.ru
The present literature review summarizes current information on the role of heat shock proteins in the genesis of physiological and pathological states in humans and animals. Their important role in controlling the process of proper protein folding into a spatial structure is noted, which is of key importance for the course of adaptive reactions. According to a number of sources, heat shock proteins also play a protective role in relation to the mitochondrial and nuclear structures of cells of various organs and systems. There is evidence of the heat shock proteins participation in the cytokine regulation system, the processes of peroxide homeostasis, energy exchange, etc. The authors suggest that studying their level in a premature newborn will create a more complete picture of the nature of stress reactions course and characteristics in the early neonatal period.
Key words: heat shock proteins, stress, adaptation.
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