Probability of inheritance and features of epilepsy in children born to epileptic parents
D.V. MOROZOV
Kazan State Medical Academy, 11 Mushtari St., Kazan, Russian Federation, 420012
Morozov D.V. — Assistant of the Department of Neurology and Neurosurgery, tel. (843) 2734909, e-mail:kiverkot@mail.ru
The article contains information on a group of 100 children born to epileptic parents. All children went through video-EEG evaluation with a sleep episode and thorough, neurological examination; MRI evaluation of the brain was conducted if necessary. During examination the epilepsy form was verified in all children in accordance with the criteria of International League Against Epilepsy. The author describes the probability of epilepsy inheritance, its forms, features of electroencephalographic changes and changes in neurological status in the examined group of children. As a result of the carried out research, a high percentage of inheritance was found, as well as frequent changes in neurological status of children, especially those whose mothers suffered from epilepsy. In children born to epileptic mothers the earlier onset of epilepsy was noted. Besides, in children with the early onset of the disease the frequency of attacks was much higher than in children with the disease onset after the age of three. In children with epilepsy onset before three years the probability of remission was significantly lower. In the children who had neurological status disorders the onset of epilepsy was noted in earlier age.
Key words: epilepsy, parents with epilepsy, EEG, neurological status.
REFERENCES
1. Wolfgang Losher. Mechanisms of drug resistence. Epileptic disord., 2005, vol. 7 (suppl. 1). pp. 3-9.
2. Prusakov V.F. Clinical and epidemiological characteristics of childhood epilepsy in Kazan. Kazanskiy meditsinskiy zhurnal, 2006, vol. 87, no. 2, pp. 111-114 (in Russ.).
3. Karlov V.A. Women’s epilepsy. Zhurnal nevrologii i psikhiatrii, 2006, no.1, pp. 41-46 (in Russ.).
4. Astedt B. Antenatal drugs affecting status of the fetus and the newborn. SeminThrombHemost, 1995, vol. 21, pp. 364-370.
5. Hiilesma V.K. Pregnancy and birth in women with epilepsy. Neurology, 1992, vol. 42 (suppl. 5), pp. 8-11.
6. Choi H., Winawer M., Kalachikov S. et al. Classification of partial seizure symptoms in genetic studies of the epilepsies. Neurology, 2006, vol. 66, pp. 1648-1653.
7. Hesdorffer D.C., Logroscino G., Benn E.K. et al. Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota. Neurology, 2011, vol. 76, pp. 23-27.
8. Helbig K.L., Bernhardt B.A., Conway L.J. et al. Genetic risk perception and reproductive decision making among people with epilepsy. Epilepsia, 2010, vol. 51, pp. 1874-1877.
9. Berkovic S.F., Howell R.A., Hay D.A. et al. Epilepsies in twins: genetics of the major epilepsy syndromes. Ann Neurol., 1998, vol. 43, pp. 435-45.
10. Annegers J., Hauser W.A., Anderson B.E. Risk of seizures among relatives of patients with epilepsy: families in a defined population. Genetic basis of the epilepsies. New York: Raven Press; 1982. Pp. 151-9.