S.V. SHTAIMETS¹, T.S. CHENCOVA¹, A.A. MINEEVA², I.V. PIS’MENNYJ¹, JU.V. LALOV², S.V. UGNICH¹, M.V. MAZHITOVA¹, R.A. NESTEROVA¹

 ¹City Polyclinic No. 3, Omsk

²Omsk State Medical University, Omsk

 Contact details:

Shtaimets S.V. — Head of the Neurology daycare center

Address: 26a Vilyams St., Omsk, Russian Federation, 644060, tel.: +79043215976, e-mail: steinmetz_stas@mail.ru

Diabetes mellitus is one of the most common diseases in the outpatient unit, leading to many lesions of various organs and systems. One of the most threatening late complications is diabetic foot syndrome, which can lead to a lower limb amputation.

The purpose — to evaluate the effect of combined therapy of diabetic polyneuropathy on the prevention of late trophic complications of diabetes mellitus in the long term.

Material and methods. Statistical data on the overall incidence of diabetes mellitus, data on the number of patients treated in the daycare center for diabetic polyneuropathy and the number of patients with trophic disorders of the lower extremities observed by surgeons in 2015–2022, and the number of amputations performed.

Results. We studied the effectiveness of combined therapy with thioctic acid and B vitamins, used for the treatment of diabetic polyneuropathy, for the long-term prevention of trophic complications in patients observed in City Polyclinic No. 3 for diabetes mellitus for 2015–2022.

Conclusions. Regular therapy for diabetic polyneuropathy in a daycare hospital statically significantly (p < 0.001) decreases the risk of trophic disorders of the lower extremities, reduces the need for surgical treatment, and also decreases the risk of amputations.

Key words: diabetes mellitus, diabetic polyneuropathy, complications, amputation, thioctic acid, B vitamins.

REFERENCES

1. Iqbal Z., Azmi S., Yadav R. et al. Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy. Clin. Ther, 2018, vol. 40 (6), pp. 828–849. DOI: 10.1016/j.clinthera.2018.04.001
2. Dedov I.I., Shestakova M.V., Vikulova O.K. et al. Epidemiological characteristics of diabetes in the Russian Federation: clinical and statistical analysis according to the diabetes mellitus register on 01.01.2021. Sakharnyy diabet, 2021, vol. 24, no. 3, pp. 204–221 (in Russ.). DOI: 10.14341/DM12759.
3. Cernea S., Raz I. Management of diabetic neuropathy. Metabolism, 2021, vol. 123, p. 154867. DOI: 10.1016/j.metabol.2021.154867
4. Lechleitner M., Abrahamian H., Francesconi C. et al. Diabetic neuropathy and diabetic foot syndrome (update 2019) [article in German]. Wien Klin Wochenschr, 2019, vol. 131 (suppl 1), pp. 141–150. DOI: 10.1007/s00508-019-1487-4
5. Khramilin V.N., Zav’yalov A.N., Demidova I.Yu. Diagnosis and treatment of early stages of diabetic polyneuropathy. Meditsinskiy sovet, 2020, no. 7, pp. 56–65 (in Russ.). DOI: 10.21518/2079-701X-2020-7-56-65
6. Kamchatnov P.R., Chugunov A.V., Evzel’man M.A. Damage to the peripheral nervous system in diabetes. Nervno-myshechnye bolezni, 2016, vol. 6, no. 2. – pp. 20–26 (in Russ.). DOI: 10.17650/2222-8721-2016-6-2-20-26
7. Sloan G., Selvarajah D., Tesfaye S. Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy. Nat. Rev. Endocrinol, 2021, vol. 17 (7), pp. 400–420. DOI: 10.1038/s41574-021-00496-z
8. Levin O.S., Chimagomedova A.Sh., Gan’kina O.A. B vitamins of group B in the treatment of diabetic polyneuropathy. Sovremennaya terapiya v psikhiatrii i nevrologii, 2017, no. 3, pp. 21–26 (in Russ.).
9. Dedov I.I., Shestakova M.V., Mayorova A.Yu., red. Specialized medical care algorithms for patients with diabetes. 10th release (supplemented). Sakharnyy diabet, 2021, vol. 24, no. 1S, pp. 1–148 (in Russ.). DOI: https://doi.org/10.14341/DM12802
10. Rogova N.V., Kuz’mina T.N. A review of Russian and international clinical recommendations for the management of patients with diabetic foot syndromes. Vestnik VolGMU, 2022, vol. 19, no. 2, pp. 177–183 (in Russ.). DOI: 10.19163/1994-9480-2022-19-2-177-183
11. Kurushina O.V., Barulin A.E., Agarkova O.I. The use of parenteral vitamins in therapy of polyneuropathy. Meditsinskiy sovet, 2018, no. 18, pp. 62–66 (in Russ.). DOI: 10.21518/2079-701X-2018-18-62-66
12. Klinicheskie rekomendatsii. Sakharnyy diabet 1 tipa u vzroslykh, 2019, Ministerstvo zdravookhraneniya Rossiyskoy Federatsii: ofitsial’nyy sayt [The use of parenteral vitamins in therapy of polyneuropathy], available at: https://cr.minzdrav.gov.ru/recomend/286_1 (accessed on: 24.03.2024).
13. Klinicheskie rekomendatsii. Sakharnyy diabet 1 tipa u vzroslykh, 2022, Ministerstvo zdravookhraneniya Rossiyskoy Federatsii: ofitsial’nyy sayt [Clinical recommendations. Type 1 diabetes mellitus in adults. 2022. Ministry of Health of the Russian Federation: Official website], available at: https://cr.minzdrav.gov.ru/recomend/286_2 (accessed on: 24.03.2024).
14. Klinicheskie rekomendatsii. Sakharnyy diabet 2 tipa u vzroslykh, 2020, Ministerstvo zdravookhraneniya Rossiyskoy Federatsii: ofitsial’nyy sayt [Clinical recommendations. Type 2 diabetes in adults. 2020. Ministry of Health of the Russian Federation: Official website], available at: https://cr.minzdrav.gov.ru/recomend/290_1 (accessed on: 24.03.2024).
15. Klinicheskie rekomendatsii. Sakharnyy diabet 2 tipa u vzroslykh, 2022, Ministerstvo zdravookhraneniya Rossiyskoy Federatsii: ofitsial’nyy sayt [Clinical recommendations. Type 2 diabetes in adults. 2022. Ministry of Health of the Russian Federation: Official website], available at: https://cr.minzdrav.gov.ru/recomend/290_2 (accessed on: 24.03.2024).