A.Ph. SHAMSUTDINOV^1,3, Yu.A. TYURIN^1,2, L.T. BAYAZITOVA¹, A.A. RIZVANOV³, A.A. SHARIPHULLINA¹

¹Kazan Research Institute of Epidemiology and Microbiology of the Russian Agency for Consumer Supervision, 67 Bolshaya Krasnaya Str., Kazan, Russian Federation, 420015

²Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

³Kazan (the Volga Region) Federal University, 18 Kremlevskaya Str., Kazan, Russian Federation, 420008 

Shamsutdinov A.Ph. ― Researcher, postgraduate student of the Department of Microbiology of the Institute of fundamental medicine and biology of Kazan Federal University, tel. (843) 236-56-59, e-mail: shamsutdinov2006@yandex.ru

Tyurin Yu.A. ― Cand. Med. Sc., Leading Researcher, Head of the laboratory of immunology and the development of allergens of the Kazan Research Institute of Epidemiology and Microbiology; Assistant of the Department of Biochemistry of the Kazan Federal University, tel. (843) 238-99-79, e-mail: immunolab@yandex.ru

Bayazitova L.T. ― Cand. Med. Sc., Leading Researcher, Head of Laboratory of Microbiology of the Kazan Research Institute of Epidemiology and Microbiology, tel. (843) 236-67-91, e-mail: bajalt@mail.ru

Rizvanov A.A. ― D. Biol. Sc., Chief Researcher, Professor of the Department of genetics of the Institute of fundamental medicine and biology, Head of Unit of exploratory research of the Research and Education Center of Pharmacy of the Kazan (the Volga region) Federal University, tel. (843) 233-78-98, e-mail: rizvanov@gmail.com

Shariphullina A.A. ― Cand. Med. Sc., allergist-immunologist of the clinic of Kazan Research Institute of Epidemiology and Microbiology, tel. (843) 299-42-05, e-mail: kniem@mail.ru 

In 45 patients with various forms of atopic dermatitis was studied transformation of skin microflora at the development of atopic dermatitis and toxigenicity of Staphylococcus aureus (S. aureus) strains, distinguished in various forms of the disease. The control group consisted of 26 healthy individuals. The strains were cultured on elective nutrient media. Identification of the distinguished strains was performed by MALDI-TOF mass spectrometry. In patients with atopic dermatitis was found low incidence of taxon S. epidermidis on facial skin and high frequency of S.aureus on skin of the upper and lower extremities as compared with healthy individuals. It is found that the occurrence of toxigenic strains of S. aureus in patients with atopic dermatitis is three times higher than the number of healthy carriers of this taxon.

Key words: atopic dermatitis, Staphylococcus aureus, MALDI-TOF mass spectrometry, genes, enterotoxines.

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