I.R. GALIMOVA^1,2, A.A. EVSTRATOV¹, A.E. CHEREMISIN¹, D.R. SABIROVA¹, O.V. REMISOVA²

¹Republic Clinical Hospital, 138 Orenburgskiy trakt, Kazan, Russian Federation, 420064

²Kazan State Medical University, 49 Butlerov Str., Kazan, Russian Federation, 420012

Galimova I.R. — PhD (medicine), Associate Professor of the Obstetrics and Gynecology Department, Deputy Chief Doctor on Obstetrics and Gynecology, e-mail: Elmira-g.64@mail.ru

Evstratov A.A. — Head of Intensive Care Unit No. 2, e-mail: virineia2005@mail.ru

Cheremisin A.E. — PhD (medicine), Head of the Department of Observational Obstetrics, Assistant Lecturer of the Department of Obstetrics and Gynecology, e-mail: vasuad@yandex.ru

Sabirova D.R. — bstetrician and gynecologist, e-mail: dianochka434@gmail.com, ORCID ID: 0000-0002-7210-4525

Remisova O.V. — resident doctor of the Department of Anaesthesiology and Reanimatology, e-mail: Vodolei4444@yadex.ru

This study presents a literature review and a case of preeclampsia complicated with (H)ELLP syndrome and acute kidney lesion. Preeclampsia is a multisystem disease characterized by hypertension, pathology of the vessels of kidneys, liver and brain. These clinical manifestations occur due to endothelial dysfunction, vessel constriction and ischemia of target organs. Preeclampsia develops due to the abnormal placental angiogenesis during pregnancy, caused by the high level of angiogenic inhibitors, soluble fms-like tyrosine kinase and soluble endoglin.

There are various complications of preeclampsia. HELLP syndrome is a severe complication characterized by the increased level of liver transaminase and thrombocytopenia. The hemodynamic and endothelial changes combined with the volume deficit make kidneys more vulnerable to acute lesions.

Key words: preeclampcia, (H)ELLP syndrome, acute tubular necrosis, acute kidney cortical necrosis.

(For citation: Galimova I.R., Evstratov A.A., Cheremisin A.E., Sabirova D.R., Remisova O.V. Pregnancy-related acute kidney injury in preeclampsia complicated with (H)ELLP syndrome. Practical Medicine. 2018)

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