Prediction of chronic kidney disease in children after acute kidney injury
I.V. BARINOV, O.V. BORISOVA
Samara State Medical University, Samara
Contact:
Borisova O.V. ― MD, Professor of the Department of Children’s Infections
Address: 89 Chapaevskaya Str., 443099, Samara, Russian Federation, tel. (846) 333-30-86, e-mail: olgaborisova74@mail.ru
In children, chronic kidney disease (CKD) is often an outcome of acute kidney injury (AKI). The objective of this study is to estimate the immediate and remote outcomes in patients who suffered hemolytic uremic syndrome, AKI; to predict probability of CKD development.
Material and methods. 61 children after AKI were studied. Prediction of the probability of disease progression was performed by A. Walda sequential analysis method.
Results. HUS was the main cause of AKI in children, requiring in most cases the use of replacement renal therapy methods. In the outcome, HUS was more likely to form CKD (67.2%) with rapid progression to chronic renal failure (39.4%). The nearest and remote (after 5 years) outcomes of AKI were studied. Fatality in the acute period amounted to 8.2%. The main factors of unfavorable disease prognosis are determined.
Conclusion. CKD development was observed in more than a half of patients who had AKI in anamnesis. The sequential analysis by A. Walda is a highly sensitive and specific method which allows predicting the probability of CKD development in children after HUS, AKI in anamnesis.
Key words: acute kidney injury in children, hemolytic uremic syndrome, immediate and remote outcomes, development of chronic kidney disease.
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