F.A. NASYBULLINA¹, G.R. VAGAPOVA¹, B.Yu. PASHAEV² 

¹Kazan State Medical Academy, 11 Mushtari St., Kazan, Russian Federation 420012

²Kazan State Medical University, 49Butlerova St., Kazan, Russian Federation 420012

Nasybullina F.A. — postgraduate student of the Department of Endocrinology, tel. +7-917-256-17-59, e-mail: nasybullinaf@mail.ru

Vagapova G.R. — D. med. Sc., Professor, Head of Department of Endocrinology, tel. +7-917-269-59-28, e-mail: g.r.vagapova@gmail.com

Pashaev B.Yu. — assistant at the Department of Neurology and Neurosurgery of Advanced Training Faculty and Professional Retraining, tel. +7-917-280-55-27, e-mail: bpashaev@gmail.com

In order to study the dynamics of tropic pituitary function in patients who suffered transnasal prostatectomy were examined 222 patients aged between 17 and 71 years who underwent transnasal prostatectomy.It is demonstrated that in case of macroadenomas of violations of tropic functions of pituitary in the pre-and postoperative periods are observed more frequently than in microadenomas.All patients, regardless of the size of an adenoma, must have dynamic monitoring to avoid hypopituitarism in the early and late postoperative periods (within 1, 3, 6, 12 months).

Key words: pituitary adenoma, hypopituitarism, panhypopituitarism, transnasal surgery, pituitary adenoma.

REFERENCES

1. Shan’ko Yu.G., Zhuravlev V.A. Modern approaches to the diagnosis and treatment of pituitary adenomas and other formations in chiasmosellar area. ARS MEDICA, 2009, no. 3 (13), pp. 171-181. (in Russ.).

2. Ciccarelli A., Daly A.F., Beckers A. The epidemiology of prolactinomas. Pituitary, 2005, vol. 8, no. 1, pp. 3-6. DOI: 10.1007/s11102-005-5079-0.

3. Giovanelli M., Losa M., Mortini P. Surgical therapy of pituitary adenomas. Metabolism: Clinical and Experimental, 1996, vol. 45, suppl. 1, pp. 115-116.

4. Dedov I.I., ed. Klinicheskaya neyroendokrinologiya [Clinical neuroendocrinology]. Moscow, 2010, pp. 109-137.

5. Hadad G., Bassagasteguy L., Carrau R.L., et al. A novel reconstructive technique after endoscopic expanded endonasal approaches: Vascular pedicle nasoseptal flap. Laryngoscope, 2006, vol. 116, no. 10, pp. 1882-1886. DOI: 10.1097/01.mlg.0000234933.37779.e4.

6. Kadashev B.A., Akshulakov S.K., Alekseev S.N., et al. Adenomy gipofiza: klinika, diagnostika, lechenie [Pituitary adenomas: Clinical features, diagnosis, treatment]. Moscow, Tver’; Triada Publ., 2007. 386 p.

7. Regal M., Páramo C., Sierra S.M., Garci-Mayor R.V. Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain. Clinical Endocrinology, 2001, vol. 55, no. 5, pp. 735-740. DOI: 10.1046/j.1365-2265.2001.01406.x.

8. Fatemi N., Dusick J.R., Mattozo C., et al. Pituitary hormonal loss and recovery after transsphenoidal adenoma removal. Neurosurgery, 2008, vol. 63, no. 4, pp. 709-719. DOI: 10.1227/01.NEU.0000325725.77132.90

9. Kadashev B.A., Akshulakov S.K., Alekseev S.N., et al. Adenomy gipofiza: klinika, diagnostika, lechenie [Pituitary adenomas: Clinical features, diagnosis, treatment]. Moscow, Tver’; Triada Publ., 2007, pp. 255-259.

10. Marazuela M., Astigarraga B., Vicente A., et al. Recovery of visual and endocrine function following transsphenoidal surgery of large nonfunctioning pituitary adenomas. Journal of Endocrinological Investigation, 1994, vol. 17, no. 9, pp. 703-707.

11. Urmanova Yu.M., Shakirova M.Yu. Clinical and diagnostic aspects of growth hormone deficiency and hypopituitarism in patients with different formations in sellar area before and after treatment. Mіzhnarodniy endokrinologіchniy zhurnal, 2010, no. 5 (29), pp. 18-22. (in Russ.).

12. Sherlock M., Ayuk J., Tomlinson J.W. Mortality in patients with pituitary disease. Endocrine Reviews, 2010, vol. 31, no. 3, pp. 301-342. DOI: 10.1210/er.2009-0033.