S.L. MOROZOV^1, 2, V.K. MIRONOVA³, V.V. DLIN¹

 ¹Scientific-Research Clinical Institute of Pediatrics named after Academician Yu.E. Veltishchev of Russian National Research Medical University named after N.I. Pirogov, Moscow

²Russian National Research Medical University named after N.I. Pirogov, Moscow

³Children’s Municipal Clinical Hospital named after Z.A. Bashlyaeva, Moscow

 Contact details:

Morozov S.L. — PhD (medicine), Senior Researcher of the Department of Inherited and Acquired Kidney Diseases, Associate Professor of the Department of Hospital Pediatrics № 2 of Pediatrics Faculty

Address: 2 Taldomskaya St., Moscow, Russian Federation, 125412, tel.: +7-903-138-77-32, e-mail: mser@list.ru

 The article presents mechanisms of chronic kidney disease development both due to the fetus hypoxia and acute kidney lesion. As a result of hypoxia, babies develop kidney fibrosis and progressing of the chronic kidney disease due to the activation of multiple profibrogenic factors. Thus, all babies with prenatal hypoxia and acute kidney lesion in the postnatal period are automatically included into a risk group for the chronic kidney disease and require dynamic observation of a nephrologist.

Key words: Children, acute kidney lesion, chronic kidney disease, hypoxia, nephropathy.