S.V. BOYCHUK^1,2, O. GJOERUP²

¹Kazan State Medical University, 49 Butlerova St., Kazan, Russian Federation 420012

²University of Pittsburgh Cancer Institute, Hillman Cancer, Research Pavilion, Suite 1.4 5117 Centre Ave, Pittsburgh, PA, 15213 USA

Boychuk S.V. — D. Med. Sc., Professor, Head of Department of Pathophysiology, phone: (843) 236-75-31, e-mail: boichuksergei@mail.ru^1,2

Gjoerup Ole — Doctor of Biological Sciences, chief of laboratory of virus oncology, (412) 623-77-07, e-mail: ogv27@pitt.edu²

It was found that in terms of PML protein knockdown against the background of DNA damage, caused by chemotherapeutic agents (doxorubicin, etoposide and etc.) and radiation, happens abnormality of focal distribution of proteins which participate in DNA damages reparation by a mechanism of homologous recombination. This allows us to consider malignant neoplasms with reduced PML protein expression as potentially susceptible to chemotherapy and radiotherapy. Development of laboratory diagnostic method of chemo-and radiosensitivity of malignant tumors, based on an assessment of the ability of tumor cells to repair DNA damage, caused by chemotherapy and ionizing radiation, seems promising and will provide the right choice of tactics in the process of the patient-specific therapy of oncologic patients, as well as follow-up monitoring of its effectiveness.

Key words: DNA-damage repair, homologous recombination, PML protein, chemo- and radiosensitivity of a tumor, laboratory diagnostics.

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