E.V. ULYANINA¹, N.R. AKHMADEEV¹, L.KH. ISLAMOVA², O.S. DEMAKOVA¹, T.N. SHIGABUTDINOVA¹

 ¹Kazan City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan

²Kazan State Medical University, Kazan

Contact details:

Ulyanina E.V. — PhD (Medicine), obstetrician-gynecologist, Department of Obstetrics and Gynecology No.1

Address: 56 Chuykova St., 420103 Kazan, Russian Federation, tel.: +7 (843) 2213699, e-mail: ualena87@yandex.ru

The article presents a clinical case of pregnancy complicated by severe intrahepatic cholestasis and plasmapheresis as a treatment method for this pathology. The authors describe the therapeutic effect of ursodeoxycholic acid, ademetionine, and plasmapheresis, and the dynamics of blood chemistry and severity of clinical symptoms depending on the treatment.

Results. The plasmapheresis courses led to a temporary decrease in bile acid levels and a temporary clinical improvement.

Conclusion. The presented clinical case demonstrates the possibility of using plasmapheresis in pregnant women with severe intrahepatic cholestasis as an alternative treatment method to prolong gestational age and improve perinatal outcomes. The treatment tactics was obviously successful in this clinical case.

Key words: intrahepatic cholestasis of pregnant women, plasmapheresis, bile acids

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