P.V. PANOV¹, E.N. AKHMADEEVA¹, L.D. PANOVA¹, E. D. BAYKOV²

¹Bashkir State Medical University, 3 Lenina St., Ufa, Russian Federation 450000

²Republican Children’s Clinical Hospital, 98 Kuvykina St., Ufa, Russian Federation 450092

Panov P.V. — post-graduate student at the Department of Hospital Pediatrics, tel. +7-917-431-29-21, e-mail: panov_home@ufacom.ru

Akhmadeeva E.N. — D. med. Sc., Professor, Head of the Department of Hospital Pediatrics, tel. +7-903-312-37-57, e-mail: pediatr@ufanet.ru

Panova L.D. — D. med. Sc., Professor in the Department of Hospital Pediatrics, tel. +7-917-407-90-54, e-mail: panov_home@ufacom.ru

Baykov E.D. — D. med. Sc., Head of the Department of roentgen diagnostics of Republican Children’s Clinical Hospital, tel. +7-917-415-48-27

This article is concerned with the analysis of perinatal anamnesis and genes of the major histocompatibility complex in bronchopulmonary dysplasia (BPD) development in extremely premature infants (n=108) in comparison with premature patients of equivalent gestational age, but without BPD development (n=367). The most significant maternal and neonatal risk factors for BPD development as well as positive association with certain groups of A, B, DRB1 alleles of HLA-region loci have been determined in infants with gestational age less than 32 weeks. This confirms the possibility of the main histological compatibility complex genes’ impact on BPD development.

Key words: bronchopulmonary dysplasia, premature infants, perinatal and genetic risk factors.

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