L.V. VINNICHENKO, I.A. ISMAILOVA, V.M. DELYAGIN

National Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev of the Ministry of Health of Russia, 1 Samory Mashela Str., Moscow, Russian Federation, 117997

Vinnichenko L.V. – post-graduate student, e-mail: delyagin-doktor@yandex.ru

Ismailova I.A. – Doctor of ultrasound diagnostics, graduate student, e-mail: delyagin-doktor@yandex.ru.

Delyagin V.M. – D. Sc. (medicine), Professor, Head of the Department of Clinical Physiology, e-mail: delyagin-doktor@yandex.ru

Urolithiasis (ICD) is a condition characterized by the formation of dense solid mineral structures in the urinary system. In different regions of Russia the incidence rate of children is 18-52:100,000. As the causes of ICD in children, genetic are put in the first place, infection, water regimen, diet, and drugs are of great importance. In the clinical picture, in young children, general anxiety and vomiting prevail, in older children — typical localization of pain with characteristic irradiation, hematuria. The paramount importance in the diagnosis of ICD belongs to ultrasound (sensitivity 19-93%, specificity more than 90%). Efficiency depends on the size and position of the stone, equipment, experience of the researcher. Drug and non-drug treatments are discussed. Recommendations on interprofessional cooperation and dispensary observation are given.

 Key words: children, urolithiasis, diagnosis, treatment.

(For citation: Vinnichenko L.V., Ismailova I.A., Delyagin V.M. Pediatric aspects of urolithiasis. Practical Medicine. 2018)

REFERENCES

1. Vinnichenko L.V., Ismailova I.A., Delyagin V.M. Aspects of diagnosis of urolithiasis. Uchastkovyy pediatr, 2017; 5: 24 (in Russ.).
2. Kelvin S., Lockhart M. Nephrolithiasis/Urolithiasis Updated: Feb 23, 2010, available at: http://emedicine.medscape.com/article/381993-overview
3. Chung M. Urolithiasis and nephrolithiasis. J Am Academy PA, 2017, no. 30 (9), pp. 49-50.
4. Davydovskiy I.V. Problema prichinnosti (ehtiologii) v meditsine [The problem of causality (etiology) in medicine]. Moscow: Gosudarstvennoe izdatelʹstvo meditsinskoy literatury, 1962. 176 p.
5. Monico C., Milliner D. Genetic determinants of urolithiasis. Nat Rev Nephrol., 2011, no. 8 (3), pp. 151-162.
6. Eggerman Th. Genetic of urolithiasis. European Med J. Urology, 2014, July, available at: emjreviews.com/wp…/Review-Genetics-of-Urolithiasis.pdf
7. Borghi L., Schianchi T., Meschi T. et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med., 2002, no. 346 (2), pp. 77-84.
8. Taylor E., Curhan G. Fructose consumption and the risk of kidney stones. Kidney Int, 2008, no. 73 (2), pp. 207-212.
9. Ramello A., Vitale C. Marangella M. Epidemiology of nephrolithiasis. J Nephrol, 2000, no.13, pp. 45-50.
10. Lopez M., Hoppe B. History, epidemiology and regional diversities of urolithiasis. Pediatr Nephrol, 2010, no. 25 (1), pp. 49-59.
11. Schwarz R., Dwyer N. Pediatric kidney stones: Long-term outcomes. Urology, 2006, no. 67 (4), pp. 812-816.
12. Al-Jeburi M. The role of sex hormones in the formation of renal stones with references of urinary tract infection in Iraqui patients. World J Pharm Pharmacent Sc., 2014, no. 3 (4), pp. 352-365.
13. Bergsland K., Coe F., White M. et al. Urine risk factors in children with calcium kidney stones and their siblings. Kidney Int, 2012, no. 81 (11), pp. 1140-1148.
14. Habbig S., Beck B., Hoppe B. Nephrocalcinosis and urolithiasis in children. Kidney International, 2011, no. 80 (12), pp. 1278-1291.
15. Massey L., Liebman M., Kynast-Gales S. Ascorbate Increases Human Oxaluria and Kidney Stone Risk. The Journal of Nutrional, 2005, no. 135 (7), pp. 1673-1677.
16. Ellis F. Oxaluria. Boston Med Surg J., 1888, no. 188, pp. 64-68.
17. Narter F., Narter Feh., Sarika K. Urinary stones in neonates: dilemma between urolithiasis and nephrocalcinosis. J. Urol. Surgery., 2015, no. 1, pp. 1-6. doi: 10.4274/jus.235
18. Alpay H., Ozen A., Gokce I., Biyikli N. Clinical and metabolic features of urolithiasis in children. Pediatr nephrol., 2009, no. 24 (11), pp. 2203-2209.
19. Routh J., Graham D., Nelson C. Epidemiological trends in pediatric urolithiasis at United States freestanding pediatric hospitals. J Urol., 2010, no. 184 (3), pp. 1100-1104.
20. Apolikhin O.I., Sivkov A.V., Solntseva T.V., Komarova V.A. Epidemiology of urolithiasis in various regions of the Russian Federation. Byulletenʹ meditsinskikh Internet-konferentsiy, 2011, no. 1 (3), pp. 167-176 (in Russ.).
21. Voshchula V.I., Nitkin D.M., Lelyuk V.Yu. et al. Statistics and risk factors for urolithiasis in Belarus. Eksperimentalʹnaya i klinicheskaya urologiya, 2013, no. 2, pp. 21-26 (in Russ.).
22. Bush N., Xu L., Brown B. et al. Hospitalizations for pediatric stone disease in United States, 2002-2007. J Urol., 2010, no. 183 (3), pp. 1151-1156.
23. Fathallah-Shaykh S. Pediatric Urolithiasis. https://emedicine.medscape.com/article/983884-overview. Updated: May 15, 2018.
24. Delyagin V.M., Malʹtsev V.I., Rumyantsev A.G. Lektsii po klinicheskoy diagnostike vnutrennikh bolezney [Lectures on the clinical diagnosis of internal diseases]. Kiev: Morion, 2007. Pp. 547-589.
25. Bove P., Kaplan D., Dalrymple N. et al. Reexamining the value of hematuria testing in patients with acute flank pain. J Urol., 1999, no. 162 (3 Pt 1), pp. 685-687.
26. Palmer J., Donaher E., O’Riordan M. et al. Diagnosis of pediatric urolithiasis: role of ultrasound and computerized tomography. J Urol., 2005, no. 174 (4 Pt 1), pp. 1413-1416.
27. Lipkin M., Ferrandino M., Preminger G. Evaluation and Medical Management of Urinary Lithiasis. In: Wein A., Kavoussi L., Partin A., Peters C. (Ed.) Campbell-Walsh Urology, 11th Ed., 2016. 1200-1234.e7
28. Granberg C., Backer L. Urolithiasis in children. Pediatr. Clin. North. Am, 2012, no. 59 (4), pp. 897-908.
29. Copelowitch L. Urolityiasis in children. Pediatr. Clin. North. Am., 2012, no. 59 (4), pp. 881-896.
30. Bakkaloglu S., Schafer F. Diseases of kidney and urinary tract in children. In: Sckorecki K., Chertow G., Maarsten Ph. et al. (Ed.) Brenner and Rectors The Kidney. 10th Ed., 2016. 2308-2364.e13.
31. Schwaderer A., Cronin R., Mahan J., Bates C. Low bone density in children with hypercalciuria and/or nephrolithiasis. Pediatr Nephrol., 2008, no. 23 (12), pp. 2209-2214.
32. Pedersen S., Gaist D., Schmidt S. et al. Hydrochlothiazide use and risk of nonmelanoma cancer: a nationwide case-control study from Denmark. J. Am. Acad. Dermatol., 2018, no. 78 (4), pp. 673-681.