M.Yu.KOBERNIK, E.A.SANDAKOVA, V.D.ELKIN

Perm State Medical Academy named after E.A. Vagner, 26 Petropavlovskaya St., Perm, Russian Federation 614 000

Sandakova E.A. — D. med. Sc., Professor, Head of the Department of Obstetrics and Gynecology of Advanced Training Faculty and Professional Retraining of Specialists, tel. (8342) 244-16-81, e-mail: selena11perm@yandex.ru¹

Elkin V.D. — D. med. Sc., Professor, Head of the Department of Dermatovenereology, tel. (8342) 226-18-94, e-mail: kapitoshcka@yandex.ru¹

Kobernik M.Yu. — assistant at the Department of Dermatovenereology, tel. (8342) 226-18-94, e-mail: cobernik.m@yandex.ru¹

The article presents research results of age-related skin changes in 62 women with pathological and 60 women with physiological course of menopause. Inside each group subgroups are distinguished. The first subgroup — women with hidden and the manifest hypothyroidism (Thyroid-stimulating hormone >4,0 mcMU/ml). The second subgroup — women with euthyroid. Significant differences in skin aging are found in these subgroups. The most involutional skin changes are detected in women with pathological course of menopause with hypothyroidism. They are expressed in prevalence of dry skin type, peeling, change in color and tone of skin, expressed general gravitational ptosis and deep deforming wrinkles, reduction in the thickness of the dermis and its acoustic density.

Key words: pathological menopause, physiological menopause, menopausal skin aging, hypothyroidism.

REFERENCES

1. Smetnik V.P., Kulakov V.I., eds. Rukovodstvo po klimakteriyu [Guide to menopause]. Moscow, Medical Information Agency Publ., 2001. 685 p.

2. Dobrokhotova, Zelenskaya E.M. Livial: Effect on the skin of postmenopausal patients. Rossiyskiy vestnik akushera-ginekologa, 2009, no. 5, pp. 69-71. (in Russ.).

3. Ozerskaya O.S. Kosmetologiya [Cosmetology]. Moscow, Meditsina Publ., 2008. 568 p.

4. Araviyskaya E.R. Menopausal skin changes: Principles of modern correction. Klinicheskaya dermatologiya i venerologiya, 2007, no. 2, pp. 97-101. (in Russ.).

5. Araviyskaya E.R., Sokolovskiy E.V., et al. Rukovodstvo po dermatokosmetologii [Guide to dermatocosmetology]. Moscow, Meditsina Publ., 2008. 632 p.

6. Mirzoeva P.N., Matushevskaya E.V., Zaydieva Ya.Z. Topical phytoestrogens for involutional skin changes correction. Vestnik dermatologii i venerologii, 2009, no. 3, pp. 87-92. (in Russ.).

7. Zvychaynyy M.A., Vorontsova A.V., Enotova E.M., Antropova M.Ts., Mityashina A.M. Kontseptsiya antiageing- terapii u zhenshchin s defitsitom polovykh steroidov. Mat. VII Ross. foruma “Mat’ i Ditya” [Proc. 7^th Russ. Forum “Mother and Child”]. Moscow, “MEDI Ekspo” Publ., 2005, p. 383.