M.D. ANDREEVA

Kuban State Medical University, 4 Sedin St., Krasnodar, Russian Federation, 350063

Andreeva M.D. — Cand. Med. Sc., Associate Professor of the Department of obstetrics, gynecology and perinatology of Faculty of advanced training and professional retraining of specialists, tel. +7-918-388-61-10, e-mail: andreeva_md@mail.ru

The article reports results of the survey of 108 patients with premature detachment of normally placed placenta regarding the presence of genetically caused thrombophilia, circulating antiphospholipid antibodies and hyperhomocysteinemia. It was found that 90,7% of patients with a premature detachment of placenta have genetic thrombophilia, 21,3% — antiphospholipid syndrome, 46,3% — hyperhomocisteinemia. Antithrombotic prophylaxis with low molecular weight heparin, starting from childbearing cycle and early pregnancy in patients with a history of placental abruption and thrombophilia, makes it possible to prevent repeated complication of pregnancy.

Key words: premature detachment of placenta, thrombophilia, antiphospholipid antibodies, genetic thrombophilia, hyperhomocisteinemia, antithrombotic therapy, low-molecular heparin.

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