E.V. GOVSH, V.G. PODSEVATKIN, S.V. KIRYUKHINA, S.V. PODSEVATKINA, N.V. BOCHKAREVA

Ogarev Mordovia State University, Medical Institute, 68 Bolshevistskaya Str., Saransk, Russian Federation, 430005

Republican Psychiatric Hospital, Zvezdnyy settlement, Lyambirsky district, Republic of Mordovia, Russian Federation, 431520

 Govsh E.V. — postgraduate student of the Department of Neurology and Psychiatry, Head of the Laboratory of Clinical Immunology, tel. +7-917-993-7247, e-mail: elena.govsh@yandex.ru

Podsevatkin V.G. — D. Med. Sc., Professor, Head of the Department of Neurology and Psychiatry, Chief Doctor, tel. (8342) 38-01-21, e-mail: mrpb@mail.ru

Kiryukhina S.V. — D. Med. Sc., Professor of the Department of Neurology and Psychiatry, Deputy Chief Doctor, tel. (8342) 38-01-21, e-mail: krsv55@mail.ru

Podsevatkina S.V. — Cand. Med. Sc., Associate Professor of the Department of Neurology and Psychiatry, Head of Intensive Therapy Department, tel. (8342) 38-01-21, e-mail: mrpb@mail.ru

Bochkareva N.V. — Assistant of the Department of Neurology and Psychiatry, tel. (8342) 38-01-21, e-mail: mrpb@mail.ru

The state of immune and hormonal profile was studied, as well as gas and electrolyte composition of blood in patients with hysterical disorders; the dynamics of the studied indices was traced under the influence of complex treatment with the use of antioxidant, immunocorrector, hyperbaric oxygenation in comparison with traditional therapy. The study involved 80 patients with conversion disorders. Depending on the type of therapy they was divided into 2 equal groups: patients of the 1^st group received traditional treatment, of the 2^nd group ― traditional treatment in combination with mexidol, timalin, and hyperbaric oxygenation. It was shown that conversion disorders are accompanied by changes in immune responses in the form of disimmunoglobulin, increased number of the circulating immune complexes of the fine fraction, of the hormonal profile in the form of increased cortisol and prolactin, and increase the activity of thyroid hormones. Patients with hysterical symptoms showed changes in gas and electrolyte composition of the blood in the form of lower partial tension of oxygen, carbon dioxide, raising the blood pH in comparison with healthy donors. The use of integrated therapy, combining traditional medicines with mexidol, timalin and hyperbaric oxygenation contributes to the restoration of humoral factors of the immune system, especially immunoglobulin fractions and circulating immune complexes and optimizes the content of hormones of the adrenal glands and the thyroid gland. In the blood of patients under the influence of complex treatment we observed normalization of acid-alkaline reaction of blood, partial pressure of oxygen and carbon dioxide. Using only traditional therapy in the treatment of hysterical disorders did not show proper recovery of the investigated laboratory parameters of blood.

Key words: conversion disorders, gas-electrolyte composition, immune and hormonal responses, мexidol, timalin, hyperbaric oxygenation.

REFERENCES

1. Churkin A.A. Epidemiologiya psikhicheskikh rasstroystv (Psikhiatriya: natsional’noe rukovodstvo) [Epidemiology of Mental Disorders (Psychiatry: national leadership)]. Moscow: GEOTAR-Media, 2009. Pp. 88-98.
2. Podsevatkin V.G. O sostoyanii psikhiatricheskoy sluzhby Respubliki Mordoviya: (Kon»yunkturnyy obzor za 2014 god) [On the state of mental health services of the Republic of Mordovia (A market review in 2014)]. Saransk: Izd-vo Mordov. un-ta, 2014. 148 p.
3. Semke V.Ya., Vetlugina T.P., Nevidimova T.I. et al. Klinicheskaya psikhoneyroimmunologiya [Clinical psychoneuroimmunology]. Tomsk: OOO RASKO, 2003. 300 p.
4. Aleksandrovskiy Yu.A., Chekhonin V.P. Klinicheskaya immunologiya pogranichnykh psikhicheskikh rasstroystv [Clinical immunology borderline mental disorders]. Moscow: Meditsina, 2005. 310 p.
5. Podsevatkin V.G., Kiryukhina S.V., Podsevatkina S.V. et al. The pathogenetic mechanisms of development of stress-mediated disorders and possibilities of their pharmacological correction. Psikhicheskoe zdorov’e, 2012, no. 2, pp. 76-93 (in Russ.).
6. Podsevatkin V.G., Kostin Ya.V., Balashov V.P. et al. Glava 12. Giperbaricheskaya oksigenatsiya v psikhiatrii (Rukovodstvo po giperbaricheskoy meditsine pod redaktsiey S.A. Baydina, A.B. Gramenitskogo, B.A. Rubinchika) [Chapter 12. Hyperbaric oxygen therapy in psychiatry (Guide to hyperbaric medicine, edited by Baidin S.A., Gramenitskiy A.B., Rubinchik B.A.)]. Moscow: Meditsina, 2008. 560 p.
7. Shapman C.R., Tuckett R.P., Song C.W. Pain and stress in a systems perspective: Reciprocal neural, endocrine, and immune interactions. J. Pain, 2008, vol. 9, no. 2, rr. 122-145.
8. Heijnen C.J. Receptor regulation in neuroendocrine-immune communication: Current knowledge and future perspectives. Brain, Behav., and Immun, 2007, vol. 21, pp. 1-8.
9. Kheytts U., Gorn M. Vodno-elektrolitnyy i kisotno-osnovnoy balans: kratkoe rukovodstvo. 2-e izd., stereotip. [Horn of water and electrolyte and kisotno-base balance: a brief guide. 2nd ed., stereotype]. Moscow: BINOM. Laboratoriya znaniy, 2014. 359 p.
10. Aleksandrovskiy Yu.A. Prichiny psikhicheskikh bolezney (Psikhiatriya: natsional’noe rukovodstvo) [Causes of mental illness (Psychiatry: National leadership]. Moscow: GEOTAR-Media, 2009. Pp. 24-41.