A.N. OREL, M.A. ZAVALII

Medical Academy named after S.I. Georgievsky of Vernadsky Crimean Federal University, 5/7 Lenin Blvd, Simferopol, Crimean Republic, 295051

  Zavalii M.A. — Doc. Med. Sc., Professor, Head of the Otorhinolaryngology Department, e-mail: mariannazavalii@gmail.com, ORCID: 0000-0002-3833-7800

Orel A.N. — post-graduate student of the Otorhinolaryngology Department, e-mail: adler_an@mail.ru

 Objective. To justify clinical application of sodium deoxyribonucleinate in patients after surgical correction of endonasal structures for increasing the surgical treatment effectiveness by restoring the regenerative processes in cilia epithelium.

Materials and methods. Patients with nasal septum deviation as a result of different growth speed of bony and cartilage parts of nasal septum, and patients with traumatic origin of deviation and/or having some conditions leading to thinning of nasal mucosa. The patients were divided into groups with and without post-operative application of sodium deoxyribonucleinate.

Results. In groups with application of sodium deoxyribonucleinate, the processes of regeneration passed quicker compared with the control group. Application of the drug shortened the use of nasal vasoconstrictors.

Conclusion. Applying drugs with nucleic acids is effective in postoperative management of patients after surgical interventions on endonasal structures.

Key words: nasal breathing, surgical treatment, mucociliary transport, deoxyribonucleic acid.

(For citation: Zavalii M.A., Orel A.N. Particularities of patient management after surgical correction of intranasal structures of nasal cavity. Practical Medicine. 2018)

REFERENCES

1. Meshcheryakov K.L., Lyutova N.V. The value of nasal breathing and the reasons for its violation. Rossiyskaya rinologiya, 2006, no. 4, pp. 32–36 (in Russ.).
2. Abdurashitov R.Sh. Anatomical aberrations causing impaired respiratory function of the nose. Rossiyskaya rinologiya, 2005, no. 2, p. 14 (in Russ.).
3. Nosulya E.V., Kim I.A., Dudkin S.V. Features of intranasal architectonics in patients with polypous rhinosinusitis. Rossiyskaya rinologiya, 2005, no. 2, p. 97 (in Russ.).
4. Piskunov V.S., Mezentseva O.Yu. Functional endoscopic operations on the nasal septum. Rossiyskaya rinologiya, 2006, no.1, pp. 16–19 (in Russ.).
5. Piskunov G.Z., Angotoeva I.B., Isabaeva N.V. The functional state of the larynx in patients with curvature of the nasal septum. Kremlevskaya meditsina. Klinicheskiy vestnik, 2013, no. 1, pp. 58–62 (in Russ.).
6. Anikeeva Z.I., Avdeeva S.N., Bondareva A.V. Clinical and functional features of diseases of the upper respiratory tract and larynx in various groups of the population of the metropolis according to the data of medical examination and appealability to the clinic. Ros. Otorinolaringologiya, no. 6 (43), 2009, pp. 3–11 (in Russ.).
7. Mezentseva O.Yu., Piskunov V.S., Dolzhikov A.A. Morphological and morphometric changes in the mucous membrane of the nasal cavity with curvature of the nasal septum. Rossiyskaya rinologiya, 2005, no. 2, p. 31 (in Russ.).
8. Evseeva V.V. Nasal cycle in the curvature of the nasal septum. Rossiyskaya rinologiya, 2005, no. 2, p. 21 (in Russ.).
9. Pukhlik S.M., Gaponyuk A.V. Studying the mechanism of drug dependence development after long-term use of nasal decongestants in rhinitis patients, methods of diagnosis and treatment. Zhurnal ushnykh, nosovykh i gorlovykh bolezney, 2002, no. 4, pp. 57–63 (in Russ.).
10. Achim G. Beule. Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses. GMS Current Topics in Otorhinolaryngology — Head and Neck Surgery, 2010, vol. 9, pp. 1–24.
11. Watelet J.B., Bachert C., Gevaert P., Van Cauwenberge P. Wound healing of the nasal and paranasal mucosa: a review. Am J. Rhinol, 2002, vol. 16, pp. 77–84.
12. Vasina L.A. Restoration of the structure and functions of the nasal mucosa in the postoperative period in patients with curvature of the nasal septum and chronic hypertrophic rhinitis. Vestnik otorinolaringologii, 2009, no. 2, pp. 33–35 (in Russ.).
13. Antogoeva I.B., Vasil’eva E.M. Postoperative management of patients with polypous and polypous purulent rhinosinusitis. Rossiyskaya rinologiya, 2005, no. 2, pp. 124–125 (in Russ.).
14. Fedyanina L.N., Besednova N.N., Epshteyn L.M. et al. Drugs and biologically active food supplements based on nucleic acids of different origin. Tikhookeanskiy meditsinskiy zhurnal, 2007, no. 4, pp. 9–12 (in Russ.).
15. Primenenie Derinata v khirurgii: Posobie dlya praktikuyushchikh vrachey, pod red. Kaplinoy E.N. i Chernova V.N. [The use of Derinat in surgery: A Handbook for practicing physicians. Ed. By Kaplina E.N. and Chernov V.N]. Tver: Triada, 2008. 64 p.
16. Dugina V.V. Influence of licopid and Derinat on the activity of lysozyme as a factor of nonspecific immune defense in chronic gastric ulcer and duodenal ulcer. Meditsinskiy al’manakh, 2010, no. 3 (12), pp. 201–203 (in Russ.).
17. Mangusheb A.R., Rafailov V.V., Svatko L.G. The effectiveness of Derinat in the treatment of chronic adenoiditis in children. Vestnik otorinolaringologii, 2008, no. 6, pp. 33–34 (in Russ.).
18. Bakulina L.S., Pluzhnikov N.N., Ovsyannikov Yu.M. On mucolytic therapy in productive rhinosinusitis. Rossiyskaya rinologiya, 2005, no. 2, pp. 14–15 (in Russ.).
19. Zavaliy M.A., Balabantsev A.G., Zagorul’ko A.K., Orel A.N. The influence of a surfactant-containing drug on the ultrastructure of the ciliated epithelium in acute purulent sinusitis in the experiment. Zhurnal ushnykh, nosovykh i gorlovykh bolezney, 2009, no. 6, pp. 14–19 (in Russ.).
20. Mokronosova M.A. Irrigation therapy of the nasal cavity from the standpoint of evidence-based medicine. Vestnik otorinolaringologii, 2009, no. 1, pp. 51–53 (in Russ.).
21. Kobylyanskiy V.I. Mukotsiliarnaya sistema: fundamental’nye i prikladnye aspekty [The mucociliary system: fundamental and applied aspects]. Moscow: Binom, 2008, 416 p.