S.R. SHAKIRZYANOVA^1,2, G.M. AKHMEDOVA^1,2, M.A. YAKUPOV^1,2

¹Republic Clinical Neurologic Centre of the Tatarstan Ministry of Healthcare, 13 Vatutin Str., Kazan, Russian Federation, 420021

²Kazan State Medical Academy, 36 Butlerov Str., Kazan, Russian Federation, 420012

 Shakirzyanova S.R. ― post-graduate student of the Department of Neurology and Manual Therapy, tel. (843) 278-23-17, e-mail: sofi.shakirzyanova@yandex.ru

Akhmedova G.M. ― Cand. Med. Sc., Associate Professor of the Department of Neurology and Manual Therapy, tel. (843) 278-97-28, e-mail: guzel29@mail.ru

Yakupov M.A. ― post-graduate student of the Department of Neurology and Manual Therapy, tel. (843) 278-23-17, e-mail: yaku-marat@yandex.ru

Paroxysmal disorders of non-epileptic genesis with multiple sclerosis remain an insufficiently studied topic. The study objective was to study the main clinical and anamnestic, neurophysiological and neuroimaging characteristics of paroxysmal disorders of non-epileptic genesis caused by focal lesions of the central nervous system due to multiple sclerosis. Patients and methods: 101 patients with confirmed diagnosis of MS were examined. They were divided into two groups: group 1 ― 51 patients with paroxysmal impairment of non-epileptic genesis, group 2 ― without paroxysmal disturbances. Anamnestic data were collected; the patients underwent a clinical examination; visual evoked potential (VEP), transcranial magnetic stimulation (TMS), somato-sensoric evoked potentials (SEP), long latent reflexes (LLR) and magnetic-resonance tomography (MRI) was performed. Results and conclusions: The prevalence of non-epileptic paroxysms among patients with MS in RT was 8.3%. Anamnestic data, differences in neurophysiological data as compared to the control group were determined, and the relationship between focal CNS lesion and non-epileptic paroxysmal phenomena was revealed.

Key words: demyelinating diseases, multiple sclerosis, paroxysmal disorders, neurophysiology.

(For citation: Shakirzyanova S.R., Akhmedova G.M., Yakupov M.A. Paroxysmal disorders of non-epileptic genesis with multiple sclerosis. Practical Medicine. 2018)

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