A.I. FAZULZYANOVA, S.V. TKACHEVA, A.K. KHUSAINOVA, N.F. GAYFUTDINOV, R.I. GULIEV

Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan

 Contact:

Fazulzyanova A.I. ― PhD (medicine), Associate Professor of the Department of Infectious Diseases

Address: 49 Butlerov Str., Kazan, Russian Federation, 420012, tel. +7-917-877-34-67, e-mail: al-faz@mail.ru

In the diagnosis of liver fibrosis, the biopsy remains the «gold standard», however today non-invasive methods come to the fore ― determination of serum markers of fibrosis and transient elastometry (TE).

Objective ― study of indicators of non-invasive methods for evaluating liver fibrosis in patients with chronic HCV infection who received antiviral therapy (AVT).

Material and methods. A retrospective analysis of case reports of 42 patients with chronic HCV infection who underwent TE before the start of the AVT and 6-12 months after its completion and were calculated 3 fibrosis indices.

Results. In patients with liver cirrhosis, average TE values of 21.26±1.598 kPa before treatment and 12.094±1.106 kPa 6 months after treatment were observed (p<0.001); AAR index> 1 before treatment in 21%, after ― in 72.7% (p<0.001); APRI index before treatment ≥1.5 in 63%, after ― in 0% (p<0.001); FIB-4 index before treatment ≥1.5 in 84%, after ― in 66% (p<0.001). A strong direct correlation between elastometry and the APRI and FIB-4 indices after treatment was noted (0,86 и 0,82 appropriately).

Conclusion. Non-invasive methods allow diagnosing severe fibrosis before development of complications and evaluating it in dynamics. The most sensitive fibrosis index is FIB-4.

Key words: chronic hepatitis C, liver fibrosis, liver cirrhosis, transient elastometry, AAR, APRI, FIB-4.

(For citation: Fazulzyanova A.I., Tkacheva S.V., Khusainova A.K., Gayfutdinov N.F., Guliev R.I. Non-invasive methods for the diagnosis of liver fibrosis in chronic HCV infection. Practical medicine. 2019. Vol. 17, №8, P. 44-47)

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